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    Sec62 SEC62 homolog, preprotein translocation [ Mus musculus (house mouse) ]

    Gene ID: 69276, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sec62provided by MGI
    Official Full Name
    SEC62 homolog, preprotein translocationprovided by MGI
    Primary source
    MGI:MGI:1916526
    See related
    Ensembl:ENSMUSG00000027706 AllianceGenome:MGI:1916526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HTP1; Dtrp1; Tloc1; 3100002M17Rik
    Summary
    Predicted to be involved in post-translational protein targeting to membrane, translocation. Predicted to act upstream of or within post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 31.7), frontal lobe adult (RPKM 26.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sec62 in Genome Data Viewer
    Location:
    3 A3; 3 14.29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30847025..30875412)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30792876..30821263)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462 Neighboring gene STARR-seq mESC enhancer starr_07301 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene predicted gene, 33590 Neighboring gene predicted gene, 42198 Neighboring gene predicted gene, 42199 Neighboring gene G protein-coupled receptor 160

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma. Wemmert S, et al. Oncol Lett, 2016 Mar. PMID 26998059, Free PMC Article
    2. Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. Conti BJ, et al. Mol Cell, 2015 Apr 16. PMID 25801167, Free PMC Article
    3. Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. Fumagalli F, et al. Nat Cell Biol, 2016 Nov. PMID 27749824
    4. Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation. Jadhav B, et al. Nat Commun, 2015 Dec 4. PMID 26634806, Free PMC Article
    5. Sec62 protein mediates membrane insertion and orientation of moderately hydrophobic signal anchor proteins in the endoplasmic reticulum (ER). Reithinger JH, et al. J Biol Chem, 2013 Jun 21. PMID 23632075, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis
      Title: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
    2. Interaction of ribosomes and Sec62 with the core Sec61 translocon is mutually exclusive.
      Title: Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
    3. The Sec62 protein plays a role in post-translational transport of presecretory proteins into endoplasmic reticulum.
      Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translocation protein SEC62
    Names
    SEC62 homolog
    TP-1
    translocation protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357528.1 → NP_001344457.1  translocation protein SEC62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158135
      Conserved Domains (2) summary
      pfam03839
      Location:170 → 304
      Sec62; Translocation protein Sec62
      cl27000
      Location:290 → 369
      TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...

    2. NM_027016.2 → NP_081292.1  translocation protein SEC62 isoform 2

      See identical proteins and their annotated locations for NP_081292.1

      Status: VALIDATED

      Source sequence(s)
      AC158135, DV657309
      Consensus CDS
      CCDS17286.1
      UniProtKB/Swiss-Prot
      Q6NX81, Q8BU14
      Related
      ENSMUSP00000029256.8, ENSMUST00000029256.9
      Conserved Domains (1) summary
      pfam03839
      Location:170 → 292
      Sec62; Translocation protein Sec62

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      30847025..30875412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU14.1 GenPept UniProtKB/Swiss-Prot:Q8BU14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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