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    NVJ3 Nvj3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NVJ3
    Official Full Name
    Nvj3p
    Primary source
    SGD:S000002587
    Locus tag
    YDR179W-A
    See related
    AllianceGenome:SGD:S000002587; FungiDB:YDR179W-A; VEuPathDB:YDR179W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in vacuole-ER tethering. Located in nucleus-vacuole junction. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NVJ3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (819433..820824)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase membrane anchor subunit SDH4 Neighboring gene Csn9p Neighboring gene cohesin-loading factor complex subunit SCC2 Neighboring gene Sas4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. Henne WM, et al. J Cell Biol, 2015 Aug 17. PMID 26283797, Free PMC Article
    2. Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation. Sharmin T, et al. Biochem Biophys Res Commun, 2021 May 7. PMID 33740659
    3. The vacuole controls nucleolar dynamics and micronucleophagy via the NVJ. Tasnin MN, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33706099
    4. Lipid droplet biogenesis is spatially coordinated at ER-vacuole contacts under nutritional stress. Hariri H, et al. EMBO Rep, 2018 Jan. PMID 29146766, Free PMC Article
    5. Membrane contact sites regulate vacuolar fission via sphingolipid metabolism. Hanaoka K, et al. Elife, 2024 Mar 27. PMID 38536872, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in vacuole-ER tethering ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nvj3p
    NP_010465.4
    • Protein with a potential role in tethering ER and vacuoles; localizes to nucleus-vacuole junctions in an Mdm1p-dependent manner; contains a lipid-binding PXA domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      819433..820824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180487.3 → NP_010465.4  TPA: Nvj3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010465.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSG2, Q03983, Q03984
      UniProtKB/TrEMBL
      G2WAS8
      Conserved Domains (1) summary
      pfam02194
      Location:98 → 246
      PXA; PXA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03983.2

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