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    FLR1 Flr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FLR1
    Official Full Name
    Flr1p
    Primary source
    SGD:S000000212
    Locus tag
    YBR008C
    See related
    AllianceGenome:SGD:S000000212; FungiDB:YBR008C; VEuPathDB:YBR008C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables fluconazole transmembrane transporter activity. Involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FLR1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (252563..254209, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene succinate-semialdehyde dehydrogenase (NAD(P)(+)) Neighboring gene Dsf2p Neighboring gene histone H4 Neighboring gene histone H3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative modeling of the Saccharomyces cerevisiae FLR1 regulatory network using an S-system formalism. Calçada D, et al. J Bioinform Comput Biol, 2011 Oct. PMID 21976379
    2. Discovery of Pyruvate Kinase as a Novel Target of New Fungicide Candidate 3-(4-Methyl-1,2,3-thiadiazolyl)-6-trichloromethyl-[1,2,4]-triazolo-[3,4- b][1,3,4]-thiadizole. Zhao B, et al. J Agric Food Chem, 2018 Nov 21. PMID 30350975
    3. Capisterones A and B, which enhance fluconazole activity in Saccharomyces cerevisiae, from the marine green alga Penicillus capitatus. Li XC, et al. J Nat Prod, 2006 Apr. PMID 16643022, Free PMC Article
    4. Characterization of complex regulatory networks and identification of promoter regulatory elements in yeast: "in silico" and "wet-lab" approaches. Mira NP, et al. Methods Mol Biol, 2012. PMID 22113266
    5. Multiple Yap1p-binding sites mediate induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents. Nguyên DT, et al. J Biol Chem, 2001 Jan 12. PMID 11056165

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yap1-mediated canthin-6-one resistance involves the plasma membrane major-facilitator superfamily efflux pump Flr1, but not the vacuolar ATP-binding-cassette transporter Ycf1.
      Title: The MFS-type efflux pump Flr1 induced by Yap1 promotes canthin-6-one resistance in yeast.
    2. An S-system formalism was used to model the interactions of a five-gene network encoding four transcription factors (Yap1, Yrr1, Rpn4 and Pdr3) regulating the transcriptional activation of the FLR1 gene.
      Title: Quantitative modeling of the Saccharomyces cerevisiae FLR1 regulatory network using an S-system formalism.
    3. This activation of FLR1 transcription is fully dependent on Yap1p and is reduced (by 50%) in the absence of Rpn4p, Yrr1p or Pdr3p.
      Title: Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3, and Yrr1.
    4. Data suggest that expression of FLR1 can be regulated by phospholipase C, a component of a signal transduction pathway, and by Mediator, a general transcription factor.
      Title: Expression of FLR1 transporter requires phospholipase C and is repressed by Mediator.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables fluconazole transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fluconazole transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fluconazole transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Flr1p
    NP_009562.1
    • Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      252563..254209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178356.1 → NP_009562.1  TPA: Flr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ09, P38124
      UniProtKB/TrEMBL
      N1P6D3
      Conserved Domains (1) summary
      cd17323
      Location:106 → 540
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38124.1

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