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    GEA1 Arf family guanine nucleotide exchange factor GEA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GEA1
    Official Full Name
    Arf family guanine nucleotide exchange factor GEA1
    Primary source
    SGD:S000003792
    Locus tag
    YJR031C
    See related
    AllianceGenome:SGD:S000003792; FungiDB:YJR031C; VEuPathDB:YJR031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in Golgi vesicle transport; actin cytoskeleton organization; and macroautophagy. Located in Golgi cis cisterna. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GEA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (486586..490812, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Rbh2p Neighboring gene peptidylprolyl isomerase CPR7 Neighboring gene Rav1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mossessova E, et al. Mol Cell, 2003 Dec. PMID 14690595
    2. Interaction between Sec7p and Pik1p: the first clue for the regulation of a coincidence detection signal. Gloor Y, et al. Eur J Cell Biol, 2010 Aug. PMID 20434792
    3. Nucleotide exchange on ARF mediated by yeast Gea1 protein. Peyroche A, et al. Nature, 1996 Dec 5. PMID 8945477
    4. The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast. Peyroche A, et al. J Cell Sci, 2001 Jun. PMID 11493664
    5. Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments. Gustafson MA, et al. Mol Biol Cell, 2017 Dec 1. PMID 28978742, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arf family guanine nucleotide exchange factor GEA1
    NP_012565.1
    • Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      486586..490812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181689.1 → NP_012565.1  TPA: Arf family guanine nucleotide exchange factor GEA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012565.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWK4, P47102
      UniProtKB/TrEMBL
      G2WH37, N1P118
      Conserved Domains (1) summary
      COG5307
      Location:283 → 1325
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47102.1

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