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    TOM71 protein channel TOM71 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOM71
    Official Full Name
    protein channel TOM71
    Primary source
    SGD:S000001159
    Locus tag
    YHR117W
    See related
    AllianceGenome:SGD:S000001159; FungiDB:YHR117W; VEuPathDB:YHR117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TOM72
    Summary
    Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Involved in protein targeting to mitochondrion. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOM71 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (342349..344268)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating protein DMA1 Neighboring gene Cox23p Neighboring gene origin recognition complex subunit 6 Neighboring gene histone methyltransferase SET1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats. Bömer U, et al. FEBS Lett, 1996 Mar 11. PMID 8612740
    2. Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70. Schlossmann J, et al. J Biol Chem, 1996 Jul 26. PMID 8663394
    3. The C-terminal TPR domain of Tom70 defines a family of mitochondrial protein import receptors found only in animals and fungi. Chan NC, et al. J Mol Biol, 2006 May 12. PMID 16566938
    4. The structural plasticity of Tom71 for mitochondrial precursor translocations. Li J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823510, Free PMC Article
    5. Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. Kondo-Okamoto N, et al. EMBO Rep, 2008 Jan. PMID 18007655, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. domain rearrangements in Tom71 significantly change the surface hydrophobicity and the volume of the precursor-binding pocket
      Title: The structural plasticity of Tom71 for mitochondrial precursor translocations.
    2. The complex formation between the C-terminal motif of Hsp70/Hsp90 and Tom71 could lock Tom71 in the open state where the preprotein-binding pocket of Tom71 is ready to receive preproteins.
      Title: Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.
    3. These data indicate an unexpected role for Tom70 in recruitment of soluble proteins to the mitochondrial surface, and indicate that Tom71 has a specialized role in Mfb1-mediated mitochondrial morphogenesis.
      Title: Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mitochondrion targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein channel TOM71
    NP_011985.1
    • Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      342349..344268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179247.1 → NP_011985.1  TPA: protein channel TOM71 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL67, P38825
      UniProtKB/TrEMBL
      C7GR63, N1P153
      Conserved Domains (2) summary
      TIGR00990
      Location:9 → 636
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:127 → 155
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38825.1

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