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    STD1 Std1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STD1
    Official Full Name
    Std1p
    Primary source
    SGD:S000005573
    Locus tag
    YOR047C
    See related
    AllianceGenome:SGD:S000005573; FungiDB:YOR047C; VEuPathDB:YOR047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MSN3; SFS3
    Summary
    Enables protein kinase activator activity. Involved in several processes, including pyridine nucleoside biosynthetic process; regulation of transcription by RNA polymerase II; and response to salt stress. Located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STD1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (416347..417681, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tom6p Neighboring gene ATP-dependent RNA helicase DBP5 Neighboring gene ssRNA exonuclease RAT1 Neighboring gene phospholipid-translocating ATPase RSB1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. STD1 (MSN3) interacts directly with the TATA-binding protein and modulates transcription of the SUC2 gene of Saccharomyces cerevisiae. Tillman TS, et al. Nucleic Acids Res, 1995 Aug 25. PMID 7667094, Free PMC Article
    2. DNA and protein footprinting analysis of the modulation of DNA binding by the N-terminal domain of the Saccharomyces cerevisiae TATA binding protein. Gupta S, et al. Biochemistry, 2007 Sep 4. PMID 17683121
    3. Asymmetric signal transduction through paralogs that comprise a genetic switch for sugar sensing in Saccharomyces cerevisiae. Sabina J, et al. J Biol Chem, 2009 Oct 23. PMID 19720826, Free PMC Article
    4. Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein. Ganster RW, et al. Mol Cell Biol, 1993 Jun. PMID 8497275, Free PMC Article
    5. Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism. Jarosz DF, et al. Cell, 2014 Aug 28. PMID 25171409, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative metabolism
      Title: Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.
    2. Mth1 is the primary regulator; Std1 serves to buffer the response to glucose.
      Title: Asymmetric signal transduction through paralogs that comprise a genetic switch for sugar sensing in Saccharomyces cerevisiae.
    3. The structural origins of the thermodyn. and kinetic effects of the N-term domain on DNA binding by TBP were explored in studies of TBPc (C-terminal domain of TBP) and TBP by "protein footprinting" with hydroxyl radical (*OH) side chain oxidation.
      Title: DNA and protein footprinting analysis of the modulation of DNA binding by the N-terminal domain of the Saccharomyces cerevisiae TATA binding protein.
    4. RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose.
      Title: Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nicotinamide riboside biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nicotinamide riboside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nicotinic acid riboside biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nicotinic acid riboside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Std1p
    NP_014690.1
    • Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      416347..417681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183466.1 → NP_014690.1  TPA: Std1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2B3, Q02794
      UniProtKB/TrEMBL
      C7GLH5, G2WMS8, N1P2Z7
      Conserved Domains (1) summary
      pfam17235
      Location:154 → 344
      STD1; STD1/MTH1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02794.1

    Gene LinkOut

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