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    ZNG1 GTP-dependent zinc transferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZNG1
    Official Full Name
    GTP-dependent zinc transferase
    Primary source
    SGD:S000005312
    Locus tag
    YNR029C
    See related
    AllianceGenome:SGD:S000005312; FungiDB:YNR029C; VEuPathDB:YNR029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity; enzyme activator activity; and zinc chaperone activity. Involved in cellular response to zinc ion starvation and protein maturation. Located in cytoplasm. Orthologous to several human genes including ZNG1A (Zn regulated GTPase metalloprotein activator 1A); ZNG1B (Zn regulated GTPase metalloprotein activator 1B); and ZNG1C (Zn regulated GTPase metalloprotein activator 1C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZNG1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (677199..678488, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative pyridoxal kinase BUD17 Neighboring gene peptidylprolyl isomerase family protein CPR8 Neighboring gene dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase Neighboring gene mitogen-activated protein kinase kinase kinase SSK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution yeast phenomics resolves different physiological features in the saline response. Warringer J, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14676322, Free PMC Article
    2. Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase. Pasquini M, et al. Cell Rep, 2022 May 17. PMID 35584675
    3. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
    4. Sulfate assimilation mediates tellurite reduction and toxicity in Saccharomyces cerevisiae. Ottosson LG, et al. Eukaryot Cell, 2010 Oct. PMID 20675578, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc chaperone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to zinc ion starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to zinc ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTP-dependent zinc transferase
    NP_014426.3
    • GTP-dependent zinc transferase; couples GTP hydrolysis to the activation of methionine aminopeptidase Map1p, especially during zinc starvation; deletion confers reduced fitness in saline; contains GTPase sequence motifs and a CxCC metal-binding motif

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      677199..678488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183206.3 → NP_014426.3  TPA: GTP-dependent zinc transferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014426.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1K3, P53729
      UniProtKB/TrEMBL
      A6ZSA2, B3LPL5, B5VR59, C7GLM9, C8ZFQ6, G2WL85, N1NWT7
      Conserved Domains (1) summary
      COG0523
      Location:71 → 428
      YejR; GTPase, G3E family [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53729.1

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