Nbdy negative regulator of P-body association [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nbdyprovided by MGI
Official Full Name: negative regulator of P-body associationprovided by MGI
Primary source: MGI:MGI:1917373
See related: Ensembl:ENSMUSG00000086316 AllianceGenome:MGI:1917373
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thp5; 2210013O21Rik
Summary: The protein encoded by this gene is a 43 aa peptide produced by early activated CD4+ T cells. The encoded protein helps regulate the differentiation of these cells into T helper 2 (Th2) cells. The solution structure of this protein is similar to that of vasoactive intestinal peptide, which plays a role in the differentiation of Th2 cells and Treg cells. [provided by RefSeq, Jun 2012]
Expression: Ubiquitous expression in CNS E18 (RPKM 29.6), limb E14.5 (RPKM 28.3) and 27 other tissues See more
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Genomic context

Location:: X F3; X 72.38 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (152506550..152524292)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (153723477..153741302)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation.
Title: CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AA998206 (e-PCR)
- UniSTS:248616

DXMit98 (e-PCR), detects polymorphism
- UniSTS:142911

DXMit98 (e-PCR), detects polymorphism
- UniSTS:132205

RH135908 (e-PCR)
- UniSTS:209906

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in negative regulation of cytoplasmic mRNA processing body assembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T helper cell-induced peptide 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.