Tmc4 transmembrane channel-like gene family 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmc4provided by MGI
Official Full Name: transmembrane channel-like gene family 4provided by MGI
Primary source: MGI:MGI:2669035
See related: Ensembl:ENSMUSG00000019734 AllianceGenome:MGI:2669035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables voltage-gated chloride channel activity. Involved in sensory perception of salty taste. Predicted to be located in plasma membrane. Orthologous to human TMC4 (transmembrane channel like 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 152.7), large intestine adult (RPKM 107.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.11 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3668790..3680522, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3665754..3677553, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse TMC4 is involved in the detection of chloride taste of salts.
Title: Mouse TMC4 is involved in the detection of chloride taste of salts.
TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.
Title: TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH132704 (e-PCR)
- UniSTS:215987

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mechanosensitive monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of salty taste	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-gated chloride channel TMC4

Names: transmembrane channel-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.