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    Cul9 cullin 9 [ Mus musculus (house mouse) ]

    Gene ID: 78309, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cul9provided by MGI
    Official Full Name
    cullin 9provided by MGI
    Primary source
    MGI:MGI:1925559
    See related
    Ensembl:ENSMUSG00000040327 AllianceGenome:MGI:1925559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Parc; Cul-9; mKIAA0708; 1810035I07Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Predicted to be involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Predicted to be located in cytosol. Predicted to be part of cullin-RING ubiquitin ligase complex. Is expressed in several structures, including brain; hemolymphoid system gland; muscle tissue; retina nuclear layer; and testis. Orthologous to human CUL9 (cullin 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.3), adrenal adult (RPKM 12.3) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cul9 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46811535..46857314, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46500609..46546388, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42667 Neighboring gene tau tubulin kinase 1 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cullin-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cullin-9
    Names
    p53-associated parkin-like cytoplasmic protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081335.2NP_001074804.2  cullin-9

      Status: VALIDATED

      Source sequence(s)
      AK051474, AK147675, AK162968, BP753198, CF534354, CJ110581
      Consensus CDS
      CCDS37636.2
      UniProtKB/Swiss-Prot
      Q80TT8, Q8BKL9, Q8CGC0, Q8R363, S4R1Y1
      UniProtKB/TrEMBL
      E9QP09
      Related
      ENSMUSP00000138418.2, ENSMUST00000182485.8
      Conserved Domains (7) summary
      COG5647
      Location:16941947
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cl02148
      Location:11691299
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:15971815
      Cullin; Cullin family
      pfam11515
      Location:367441
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cd20347
      Location:21502223
      BRcat_RBR_CUL9; BRcat domain found in cullin-9 (CUL-9) and similar proteins
      cd20359
      Location:22312288
      Rcat_RBR_CUL9; Rcat domain found in cullin-9 (CUL-9) and similar proteins
      cl17238
      Location:20722124
      RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46811535..46857314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246723.4XP_011245025.1  cullin-9 isoform X2

      UniProtKB/TrEMBL
      E9QP09
      Conserved Domains (8) summary
      smart00647
      Location:21832245
      IBR; In Between Ring fingers
      COG5647
      Location:17321985
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:21122162
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:17361852
      Cullin; Cullin family
      pfam01485
      Location:22762311
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:11841314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:21112162
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_011246722.4XP_011245024.1  cullin-9 isoform X1

      UniProtKB/TrEMBL
      E9QP09
      Conserved Domains (8) summary
      smart00647
      Location:21872249
      IBR; In Between Ring fingers
      COG5647
      Location:17361989
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:21162166
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:17401856
      Cullin; Cullin family
      pfam01485
      Location:22802315
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:11841314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:21152166
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. XM_006525135.5XP_006525198.1  cullin-9 isoform X3

      UniProtKB/TrEMBL
      E9QP09
      Related
      ENSMUST00000182315.8
      Conserved Domains (8) summary
      smart00647
      Location:21602222
      IBR; In Between Ring fingers
      COG5647
      Location:17091962
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:20892139
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:16121829
      Cullin; Cullin family
      pfam01485
      Location:22532288
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:11841314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:20882139
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    4. XM_006525136.5XP_006525199.1  cullin-9 isoform X4

      UniProtKB/TrEMBL
      E9QP09
      Conserved Domains (8) summary
      smart00647
      Location:21602222
      IBR; In Between Ring fingers
      COG5647
      Location:17091962
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:20892139
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:16121829
      Cullin; Cullin family
      pfam01485
      Location:22532288
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:11841314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:20882139
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain