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    Stradb STE20-related kinase adaptor beta [ Mus musculus (house mouse) ]

    Gene ID: 227154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stradbprovided by MGI
    Official Full Name
    STE20-related kinase adaptor betaprovided by MGI
    Primary source
    MGI:MGI:2144047
    See related
    Ensembl:ENSMUSG00000026027 AllianceGenome:MGI:2144047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Papk; ILPIP; ILPIPA; Syradb; Als2cr2; D1Ucla2; PRO1038; B830008M19
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Acts upstream of or within JNK cascade; cell morphogenesis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in aggresome; cytosol; and nucleus. Predicted to be part of serine/threonine protein kinase complex. Is expressed in central nervous system; liver; and retina. Orthologous to human STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.2), heart adult (RPKM 13.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stradb in Genome Data Viewer
    Location:
    1 C1.3; 1 29.2 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59012681..59034281)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58973522..58995122)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:58854474-58854775 Neighboring gene caspase 8 Neighboring gene predicted gene 28802 Neighboring gene STARR-seq mESC enhancer starr_01024 Neighboring gene STARR-seq mESC enhancer starr_01025 Neighboring gene trafficking protein, kinesin binding 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59013204-59013435 Neighboring gene STARR-seq mESC enhancer starr_01027 Neighboring gene STARR-positive B cell enhancer ABC_E982 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_01029 Neighboring gene predicted gene 29018 Neighboring gene predicted gene, 25502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle. Smith CD, et al. J Appl Physiol (1985), 2011 Dec. PMID 21903876, Free PMC Article
    2. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. Nishigaki K, et al. J Biol Chem, 2003 Apr 11. PMID 12574163
    3. STRAD pseudokinases regulate axogenesis and LKB1 stability. Veleva-Rotse BO, et al. Neural Dev, 2014 Mar 4. PMID 24594058, Free PMC Article
    4. Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis. Welch CL, et al. Mamm Genome, 1997 Aug. PMID 9250876
    5. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Barnes AP, et al. Cell, 2007 May 4. PMID 17482548

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of serine/threonine protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    STE20-related kinase adapter protein beta
    Names
    ILP-interacting protein homolog
    STRAD beta
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog
    polyploidy associated protein kinase
    pseudokinase ALS2CR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172656.6 → NP_766244.4  STE20-related kinase adapter protein beta

      See identical proteins and their annotated locations for NP_766244.4

      Status: VALIDATED

      Source sequence(s)
      AI643873, AK080096, AK140272
      Consensus CDS
      CCDS14981.1
      UniProtKB/Swiss-Prot
      Q6P922, Q8BU86, Q8BXK0, Q8K4T2, Q8K4T3
      Related
      ENSMUSP00000027185.5, ENSMUST00000027185.11
      Conserved Domains (2) summary
      smart00220
      Location:58 → 369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08226
      Location:59 → 386
      PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

    RNA

    1. NR_151686.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI643873, AK140272
      Related
      ENSMUST00000123301.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      59012681..59034281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173155.1: Suppressed sequence

      Description
      NM_173155.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4T3.1 GenPept UniProtKB/Swiss-Prot:Q8K4T3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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