H2az2 H2A.Z histone variant 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2az2provided by MGI
Official Full Name: H2A.Z histone variant 2provided by MGI
Primary source: MGI:MGI:1924855
See related: Ensembl:ENSMUSG00000041126 AllianceGenome:MGI:1924855
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H2av; H2afv; H2A.Z2; H2a.z-2; Wnt1cre; Wnt1-Cre; Wnt1::Cre; C530002L11Rik; Tg(Wnt1-cre)11Rth
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 129.3), CNS E14 (RPKM 78.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 4.01 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (6377226..6394511, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (6427226..6444511, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.
Title: Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.
Histone H2A.Z is required for androgen receptor-mediated effects on fear memory.
Title: Histone H2A.Z is required for androgen receptor-mediated effects on fear memory.
Histone variant dictates fate biasing of neural crest cells to melanocyte lineage.
Title: Histone variant dictates fate biasing of neural crest cells to melanocyte lineage.
Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells.
Title: Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells.
H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.
Title: H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.
H2A.Z.2 expression is closely associated with microglia embryonic development. A key role of H2A.Z.2 in neural progenitor cells in controlling microglial development.H2A.Z.2- and G9a-mediated H3K9me2 modifications regulate Cxcl14 transcription in microglial embryonic development.
Title: Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H2afv (e-PCR), detects polymorphism
- UniSTS:536583

H2afv (e-PCR), detects polymorphism
- UniSTS:536584

H2afv (e-PCR), detects polymorphism
- UniSTS:536585

H2afv (e-PCR), detects polymorphism
- UniSTS:536586

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	NAS Non-traceable Author Statement more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H2A.V

Names: H2A histone family, member V; H2A.Z variant histone 2; histone H2A.F/Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347064.1 → NP_001333993.1 histone H2A.V isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.

Source sequence(s)

AI851486, AL646020, BC028539, CJ069840

Consensus CDS

CCDS83779.1

UniProtKB/TrEMBL

Q5NC91, Q8R029

Related

ENSMUSP00000091037.6, ENSMUST00000093346.6

Conserved Domains (1) summary

PTZ00017
Location:3 → 90

PTZ00017; histone H2A; Provisional
NM_029938.1 → NP_084214.1 histone H2A.V isoform 1

See identical proteins and their annotated locations for NP_084214.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL646020, BC147294, CJ069840

Consensus CDS

CCDS48750.1

UniProtKB/Swiss-Prot

Q3THW5, Q5NC92, Q6ZWU0

UniProtKB/TrEMBL

B2RVP5

Related

ENSMUSP00000105359.3, ENSMUST00000109737.9

Conserved Domains (1) summary

PLN00154
Location:6 → 121

PLN00154; histone H2A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

6377226..6394511 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246426.2 → XP_030102286.1 histone H2A.V isoform X1

Conserved Domains (1) summary

PLN00154
Location:30 → 124

PLN00154; histone H2A; Provisional