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    Cdhr2 cadherin-related family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 268663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdhr2provided by MGI
    Official Full Name
    cadherin-related family member 2provided by MGI
    Primary source
    MGI:MGI:2687323
    See related
    Ensembl:ENSMUSG00000034918 AllianceGenome:MGI:2687323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm624; PC-LKC; Pcdh24
    Summary
    Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; and negative regulation of cell growth involved in contact inhibition. Predicted to be located in apical plasma membrane; brush border membrane; and microvillus membrane. Predicted to be active in plasma membrane. Orthologous to human CDHR2 (cadherin related family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 326.0), duodenum adult (RPKM 242.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdhr2 in Genome Data Viewer
    Location:
    13 B1; 13 29.03 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54849276..54884475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54701463..54736662)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54788483-54788694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54789238-54789421 Neighboring gene STARR-positive B cell enhancer ABC_E2408 Neighboring gene ring finger protein 44 Neighboring gene STARR-positive B cell enhancer ABC_E3083 Neighboring gene G protein-regulated inducer of neurite outgrowth 1 Neighboring gene synuclein, beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of intermicrovillar adhesion factor CDHR2 impairs basolateral junctional complexes in transporting epithelia. Cencer CS, et al. Mol Biol Cell, 2024 Nov 1. PMID 39292922,
    2. Adhesion-based capture stabilizes nascent microvilli at epithelial cell junctions. Cencer CS, et al. Dev Cell, 2023 Oct 23. PMID 37832537, Free PMC Article
    3. Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo. Pinette JA, et al. Mol Biol Cell, 2019 Jan 1. PMID 30403560, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of intermicrovillar adhesion factor CDHR2 impairs basolateral junctional complexes in transporting epithelia.
      Title: Loss of intermicrovillar adhesion factor CDHR2 impairs basolateral junctional complexes in transporting epithelia.
    2. CDHR2 functions to elongate microvilli and maximize their numbers on the apical surface, which together serve to increase the functional capacity of enterocyte.
      Title: Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intermicrovillar adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermicrovillar adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell growth involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth involved in contact inhibition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microvillus length ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microvillus length ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-related family member 2
    Names
    protocadherin 24
    protocadherin LKC

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033364.3 → NP_001028536.2  cadherin-related family member 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK144400, BC141301, BX630481
      Consensus CDS
      CCDS36669.1
      UniProtKB/Swiss-Prot
      B7ZP46, B9EJ32, E9Q7P9, Q3UN77
      Related
      ENSMUSP00000043596.8, ENSMUST00000037145.8
      Conserved Domains (1) summary
      cd11304
      Location:485 → 582
      Cadherin_repeat; Cadherin tandem repeat domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54849276..54884475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q7P9.1 GenPept UniProtKB/Swiss-Prot:E9Q7P9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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