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    Cdc27 cell division cycle 27 [ Mus musculus (house mouse) ]

    Gene ID: 217232, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc27provided by MGI
    Official Full Name
    cell division cycle 27provided by MGI
    Primary source
    MGI:MGI:102685
    See related
    Ensembl:ENSMUSG00000020687 AllianceGenome:MGI:102685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC3
    Summary
    Predicted to enable protein phosphatase binding activity. Acts upstream of or within neuron projection development. Predicted to be located in centrosome; mitotic spindle; and nucleoplasm. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Is expressed in brain; cerebellum; cerebral cortex; and head. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.7), placenta adult (RPKM 12.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc27 in Genome Data Viewer
    Location:
    11 E1; 11 67.79 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104393350..104441371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104502524..104550620, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene predicted gene, 22743 Neighboring gene STARR-seq mESC enhancer starr_30878 Neighboring gene STARR-seq mESC enhancer starr_30880 Neighboring gene STARR-seq mESC enhancer starr_30882 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:104286345-104286585 Neighboring gene STARR-seq mESC enhancer starr_30888 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104322909-104323210 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104330691-104330991 Neighboring gene STARR-seq mESC enhancer starr_30889 Neighboring gene STARR-seq mESC enhancer starr_30890 Neighboring gene myosin, light polypeptide 4 Neighboring gene predicted gene 11665 Neighboring gene TROVE domain family, member 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. Tugendreich S, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234252, Free PMC Article
    2. Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. Zur A, et al. EMBO J, 2001 Feb 15. PMID 11179223, Free PMC Article
    3. Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Akhter S, et al. Mol Cell Biol, 2004 Dec. PMID 15542852, Free PMC Article
    4. C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. Pawar SA, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20439707, Free PMC Article
    5. A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain. Huang J, et al. Neuron, 2015 May 6. PMID 25913861, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdc27 directs cyclin D1 to alternative degradation by anaphase promoting complex/cyclosome.
      Title: C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle protein 27 homolog
    Names
    cell division cycle 27 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285988.2 → NP_001272917.1  cell division cycle protein 27 homolog isoform 1

      See identical proteins and their annotated locations for NP_001272917.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL603709
      UniProtKB/Swiss-Prot
      A2A6Q5
      Conserved Domains (5) summary
      COG0457
      Location:507 → 768
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:573 → 601
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:641 → 673
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13181
      Location:745 → 775
      TPR_8; Tetratricopeptide repeat

    2. NM_001285989.2 → NP_001272918.1  cell division cycle protein 27 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AL603709
      UniProtKB/TrEMBL
      Q3TTW1
      Conserved Domains (5) summary
      COG0457
      Location:501 → 762
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:567 → 595
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:635 → 667
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13181
      Location:739 → 769
      TPR_8; Tetratricopeptide repeat

    3. NM_001285990.2 → NP_001272919.1  cell division cycle protein 27 homolog isoform 4

      See identical proteins and their annotated locations for NP_001272919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AL603709
      Conserved Domains (5) summary
      COG0457
      Location:373 → 634
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:439 → 467
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:507 → 539
      TPR_1; Tetratricopeptide repeat
      pfam13181
      Location:611 → 641
      TPR_8; Tetratricopeptide repeat
      pfam13424
      Location:329 → 400
      TPR_12; Tetratricopeptide repeat

    4. NM_145436.3 → NP_663411.2  cell division cycle protein 27 homolog isoform 2

      See identical proteins and their annotated locations for NP_663411.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL603709
      Consensus CDS
      CCDS36354.1
      UniProtKB/Swiss-Prot
      A2A6Q5, A2A6Q6, B2RXS0
      Related
      ENSMUSP00000091452.3, ENSMUST00000093923.9
      Conserved Domains (5) summary
      COG0457
      Location:502 → 763
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:568 → 596
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:636 → 668
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13181
      Location:740 → 770
      TPR_8; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      104393350..104441371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156600.1 → XP_036012493.1  cell division cycle protein 27 homolog isoform X4

      Conserved Domains (2) summary
      COG0457
      Location:405 → 666
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:471 → 499
      TPR; TPR repeat [structural motif]

    2. XM_036156599.1 → XP_036012492.1  cell division cycle protein 27 homolog isoform X3

      Conserved Domains (2) summary
      COG0457
      Location:441 → 702
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:507 → 535
      TPR; TPR repeat [structural motif]

    3. XM_036156597.1 → XP_036012490.1  cell division cycle protein 27 homolog isoform X2

      Conserved Domains (2) summary
      COG0457
      Location:179 → 440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245 → 273
      TPR; TPR repeat [structural motif]

    4. XM_036156596.1 → XP_036012489.1  cell division cycle protein 27 homolog isoform X2

      Conserved Domains (2) summary
      COG0457
      Location:179 → 440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245 → 273
      TPR; TPR repeat [structural motif]

    5. XM_006533052.5 → XP_006533115.1  cell division cycle protein 27 homolog isoform X2

      See identical proteins and their annotated locations for XP_006533115.1

      Conserved Domains (2) summary
      COG0457
      Location:179 → 440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245 → 273
      TPR; TPR repeat [structural motif]

    6. XM_036156598.1 → XP_036012491.1  cell division cycle protein 27 homolog isoform X2

      Conserved Domains (2) summary
      COG0457
      Location:179 → 440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245 → 273
      TPR; TPR repeat [structural motif]

    7. XM_006533050.4 → XP_006533113.1  cell division cycle protein 27 homolog isoform X1

      UniProtKB/Swiss-Prot
      A2A6Q5
      Related
      ENSMUSP00000102575.3, ENSMUST00000106962.9
      Conserved Domains (3) summary
      COG0457
      Location:508 → 769
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:574 → 602
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    8. XM_036156601.1 → XP_036012494.1  cell division cycle protein 27 homolog isoform X5

      Conserved Domains (2) summary
      COG0457
      Location:441 → 701
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:507 → 535
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A6Q5.1 GenPept UniProtKB/Swiss-Prot:A2A6Q5

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