Ccnyl1 cyclin Y-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnyl1provided by MGI
Official Full Name: cyclin Y-like 1provided by MGI
Primary source: MGI:MGI:2138614
See related: Ensembl:ENSMUSG00000070871 AllianceGenome:MGI:2138614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9630037P07Rik
Summary: Acts upstream of or within flagellated sperm motility; regulation of protein kinase activity; and spermatogenesis. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; mammary gland; and spleen. Orthologous to human CCNYL1 (cyclin Y like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 21.2), limb E14.5 (RPKM 6.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 32.74 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (64729963..64764805)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (64691041..64725646)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5
Title: Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells.
CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16.
Title: CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

UniSTS:234144 (e-PCR)
- UniSTS:234144

AW554339 (e-PCR)
- UniSTS:178403

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-Y-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097644.1 → NP_001091113.1 cyclin-Y-like protein 1

See identical proteins and their annotated locations for NP_001091113.1

Status: VALIDATED

Source sequence(s)

AK079350, AK132782, BE944301, CN668580, DV657169

Consensus CDS

CCDS48281.1

Related

ENSMUSP00000092499.4, ENSMUST00000094898.5

Conserved Domains (1) summary

pfam00134
Location:124 → 215

Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

64729963..64764805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495953.4 → XP_006496016.1 cyclin-Y-like protein 1 isoform X2

See identical proteins and their annotated locations for XP_006496016.1

UniProtKB/Swiss-Prot

D3YUJ3, E9Q226

Conserved Domains (1) summary

cd20540
Location:138 → 234

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
XM_011238499.3 → XP_011236801.1 cyclin-Y-like protein 1 isoform X1

UniProtKB/Swiss-Prot

D3YUJ3, E9Q226

Related

ENSMUSP00000109711.2, ENSMUST00000114077.8

Conserved Domains (1) summary

pfam00134
Location:197 → 288

Cyclin_N; Cyclin, N-terminal domain