EVI2B ecotropic viral integration site 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: EVI2Bprovided by HGNC
Official Full Name: ecotropic viral integration site 2Bprovided by HGNC
Primary source: HGNC:HGNC:3500
See related: Ensembl:ENSG00000185862 MIM:158381; AllianceGenome:HGNC:3500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EVDB; CD361; D17S376
Summary: Involved in positive regulation of granulocyte differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lymph node (RPKM 78.2), spleen (RPKM 77.3) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q11.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (31303770..31314054, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (32249455..32259731, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (29630788..29641072, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Assessment of Ecotropic Viral Integration Site 2B (EVI2B) Gene in Juvenile Myelomonocytic Leukemia and Neurofibromatosis Type 1 NF1 Tumors.
Title: Assessment of Ecotropic Viral Integration Site 2B (EVI2B) Gene in Juvenile Myelomonocytic Leukemia and Neurofibromatosis Type 1 NF1 Tumors.
EVI2B may be a novel prognostic marker for lung adenocarcinoma.
Title: EVI2B may be a novel prognostic marker for lung adenocarcinoma.
EVI2B is significantly downregulated in human acute myeloid leukemia samples characterized by defects in CEBPA.
Title: EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of ecotropic viral integration site 2B (EVI2B) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S2051 (e-PCR)
- UniSTS:6214

SHGC-34851 (e-PCR)
- UniSTS:75898

RH68548 (e-PCR)
- UniSTS:5024

RH17711 (e-PCR)
- UniSTS:21464

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in myeloid cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of granulocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neutrophil differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of stem cell division	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: protein EVI2B

Names: EVI-2B; ecotropic viral integration site 2B protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.