Agtr1a angiotensin II receptor, type 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agtr1aprovided by MGI
Official Full Name: angiotensin II receptor, type 1aprovided by MGI
Primary source: MGI:MGI:87964
See related: Ensembl:ENSMUSG00000049115 AllianceGenome:MGI:87964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AT1; AG2S; AT1a; AT2R1; Agtr1; AT2R1A; Agt1ar; Agtr-1a; Angtr-1a; 1810074K20Rik
Summary: Enables angiotensin type I receptor activity. Involved in gene expression; positive regulation of cytokine production; and regulation of blood pressure. Acts upstream of or within several processes, including circulatory system development; regulation of blood pressure; and regulation of smooth muscle cell apoptotic process. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; endocrine gland; extraembryonic component; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 44.0), liver adult (RPKM 31.7) and 14 other tissues See more
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Genomic context

Location:: 13 A3.2; 13 13.19 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (30520339..30566850)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (30336356..30382867)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting AGTR1 reduces AML burden and protects the heart from cardiotoxicity in mouse models.
Title: Inhibiting AGTR1 reduces AML burden and protects the heart from cardiotoxicity in mouse models.
Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na[+] Channel (ENaC).
Title: Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na(+) Channel (ENaC).
Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity.
Title: Angiotensin AT(1A) receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity.
Angiotensin II type 1a receptor deficiency alleviates muscle atrophy after denervation.
Title: Angiotensin II type 1a receptor deficiency alleviates muscle atrophy after denervation.
Genetic Deletion of AT1a Receptor or Na[+]/H[+] Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice.
Title: Genetic Deletion of AT(1a) Receptor or Na(+)/H(+) Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice.
Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.
Title: Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.
Angiotensin II receptor 1 controls profibrotic Wnt/beta-catenin signalling in experimental autoimmune myocarditis.
Title: Angiotensin II receptor 1 controls profibrotic Wnt/β-catenin signalling in experimental autoimmune myocarditis.
Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation.
Title: Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation.
Decreased angiotensin receptor 1 expression in +/- AT1 Knockout mice testis results in male infertility and GnRH reduction.
Title: Decreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction.
Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1(-/-) mice.
Title: Increased AT(1) receptor expression mediates vasoconstriction leading to hypertension in Snx1(-/-) mice.

Submit: New GeneRIF Correction See all GeneRIFs (233)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Agtr1a (e-PCR), detects polymorphism
- UniSTS:516680

PMC162282P1 (e-PCR)
- UniSTS:271470

UniSTS:256385 (e-PCR)
- UniSTS:256385

Agtr1a (e-PCR), detects polymorphism
- UniSTS:256385

Agtr1a (e-PCR), detects polymorphism
- UniSTS:256386

AI551199 (e-PCR)
- UniSTS:164520

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	IEA Inferred from Electronic Annotation more info
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables angiotensin type I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin type I receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin type I receptor activity	ISO Inferred from Sequence Orthology more info
enables angiotensin type II receptor activity	IEA Inferred from Electronic Annotation more info
enables angiotensin type II receptor activity	ISO Inferred from Sequence Orthology more info
enables bradykinin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within brain renin-angiotensin system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
involved_in dopamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within drinking behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of renal output by angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of vascular associated smooth muscle cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renin secretion into blood stream	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renin-angiotensin regulation of aldosterone production	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to salt stress	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in organelle outer membrane	IEA Inferred from Electronic Annotation more info
located_in organelle outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: type-1 angiotensin II receptor A

Names: AT1 receptor A; angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; type-1A angiotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177322.3 → NP_796296.1 type-1 angiotensin II receptor A

See identical proteins and their annotated locations for NP_796296.1

Status: VALIDATED

Source sequence(s)

AL607131, CJ066917

Consensus CDS

CCDS26415.1

UniProtKB/Swiss-Prot

P29754

UniProtKB/TrEMBL

Q32MF7, Q8BU69

Related

ENSMUSP00000070958.8, ENSMUST00000066412.8

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

30520339..30566850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516534.3 → XP_006516597.1 type-1 angiotensin II receptor A isoform X1

See identical proteins and their annotated locations for XP_006516597.1

UniProtKB/Swiss-Prot

P29754

UniProtKB/TrEMBL

Q32MF7, Q8BU69

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011244264.3 → XP_011242566.1 type-1 angiotensin II receptor A isoform X1

See identical proteins and their annotated locations for XP_011242566.1

UniProtKB/Swiss-Prot

P29754

UniProtKB/TrEMBL

Q32MF7, Q8BU69

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors