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    AIM2 protein AIM2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIM2
    Official Full Name
    protein AIM2
    Primary source
    SGD:S000000047
    Locus tag
    YAL049C
    See related
    AllianceGenome:SGD:S000000047; FungiDB:YAL049C; VEuPathDB:YAL049C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hydrolase activity. Located in cytoplasm. Orthologous to human CMBL (carboxymethylenebutenolidase homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIM2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (51855..52595, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide transporter FLC2 Neighboring gene oleate-activated transcription factor OAF1 Neighboring gene ERMES complex Ca(2+)-binding regulatory GTPase GEM1 Neighboring gene gamma-tubulin complex subunit SPC72

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Bussey H, et al. Proc Natl Acad Sci U S A, 1995 Apr 25. PMID 7731988, Free PMC Article
    2. A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Wilfling F, et al. Mol Cell, 2020 Dec 3. PMID 33207182, Free PMC Article
    3. A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Millson SH, et al. Eukaryot Cell, 2005 May. PMID 15879519, Free PMC Article
    4. Two novel effectors of trafficking and maturation of the yeast plasma membrane H(+) -ATPase. Geva Y, et al. Traffic, 2017 Oct. PMID 28727280, Free PMC Article
    5. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Hess DC, et al. PLoS Genet, 2009 Mar. PMID 19300474, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein AIM2
    NP_009350.1
    • Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      51855..52595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178194.1 → NP_009350.1  TPA: protein AIM2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPG7, P39721
      UniProtKB/TrEMBL
      A7A0B7, B5VDH1, C7GPI8, C8Z3G2, G2W8I1, N1P916
      Conserved Domains (1) summary
      pfam01738
      Location:31 → 242
      DLH; Dienelactone hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39721.1

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