Gkn2 gastrokine 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gkn2provided by MGI
Official Full Name: gastrokine 2provided by MGI
Primary source: MGI:MGI:1913534
See related: Ensembl:ENSMUSG00000030049 AllianceGenome:MGI:1913534
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bricd1b; 1810036H07Rik
Summary: Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly; neutrophil activation involved in immune response; and response to cortisol. Located in basal part of cell. Is expressed in reproductive system; stomach; trunk; and yolk sac. Orthologous to human GKN2 (gastrokine 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward stomach adult (RPKM 4021.5) See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.96 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (87350347..87356476)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (87373365..87379494)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of GKN2 Attenuates Acute Gastric Lesions Through the NLRP3 Inflammasome.
Title: Inhibition of GKN2 Attenuates Acute Gastric Lesions Through the NLRP3 Inflammasome.
these results reveal an antiinflammatory role for GKN2, provide in vivo evidence that links GKN2 loss to GC pathogenesis, and suggest GKN restoration as a strategy to restrain GC progression.
Title: Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.
Yolk sac endothelial cells were found to express low levels of Gkn2 transcript and protein.
Title: Gastrokine-2 is transiently expressed in the endodermal and endothelial cells of the maturing mouse yolk sac.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cortisol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gastrokine-2

Names: blottin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025467.1 → NP_079743.1 gastrokine-2 precursor

See identical proteins and their annotated locations for NP_079743.1

Status: PROVISIONAL

Source sequence(s)

AK007705

Consensus CDS

CCDS39546.1

UniProtKB/Swiss-Prot

Q9CQS6

Related

ENSMUSP00000032128.5, ENSMUST00000032128.6

Conserved Domains (1) summary

smart01039
Location:54 → 149

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer