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    mas masquerade [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    masprovided by FlyBase
    Official Full Name
    masqueradeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011653
    Locus tag
    Dmel_CG15002
    See related
    AllianceGenome:FB:FBgn0011653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SPH79; CG15002; cSPH79; Dmel\CG15002; Mas; SPH79
    Summary
    Involved in muscle attachment; nervous system development; and positive regulation of neuron projection development. Located in several cellular components, including axon; extracellular space; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; dorsal ectoderm anlage; epithelium; gut section; and tracheal system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mas in Genome Data Viewer
    Location:
    64A8-64A8; 3-10 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4161666..4167464, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4161666..4167464, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nab Neighboring gene long non-coding RNA:CR44529 Neighboring gene Endoplasmic reticulum oxidoreductin-1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Masquerade: a novel secreted serine protease-like molecule is required for somatic muscle attachment in the Drosophila embryo. Murugasu-Oei B, et al. Genes Dev, 1995 Jan 15. PMID 7851790
    2. Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila. Murugasu-Oei B, et al. Mech Dev, 1996 Jun. PMID 8817456
    3. Separable cis-acting control elements for expression of the white gene of Drosophila. Levis R, et al. EMBO J, 1985 Dec 16. PMID 3004962, Free PMC Article
    4. Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. Sorrosal G, et al. EMBO Rep, 2010 May. PMID 20379222, Free PMC Article
    5. Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates. Watson JD, et al. Development, 2011 Apr. PMID 21350018, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    masquerade
    Names
    CG15002-PB
    CG15002-PC
    mas-PB
    mas-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4161666..4167464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274479.1 → NP_001261408.1  masquerade, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261408.1

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00020
      Location:801 → 1037
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:802 → 1040
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_079195.3 → NP_523919.1  masquerade, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523919.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PE44, Q24019, Q960I5, Q9VZH2
      Related
      FBpp0073116
      Conserved Domains (1) summary
      cd00190
      Location:803 → 1041
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZH2.1 Q9VZH2

    Gene LinkOut

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