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    TTLL4B Tubulin tyrosine ligase-like 4B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TTLL4Bprovided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 4Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031574
    Locus tag
    Dmel_CG3964
    See related
    AllianceGenome:FB:FBgn0031574
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3964; DmCG3964; Dmel\CG3964; TTLL4
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in ciliary basal body. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval nervous system. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TTLL4B in Genome Data Viewer
    Location:
    24C8-24C8; 2-11 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3862668..3867507)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3862668..3867507)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45450 Neighboring gene long non-coding RNA:CR44078 Neighboring gene Centrosomal protein 97kDa Neighboring gene uncharacterized protein Neighboring gene cappuccino

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster. Garlapow ME, et al. Behav Genet, 2017 Mar. PMID 27704301, Free PMC Article
    2. Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen. Stielow B, et al. Mol Cell, 2008 Mar 28. PMID 18374648
    3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    4. New components of Drosophila leg development identified through genome wide association studies. Grubbs N, et al. PLoS One, 2013. PMID 23560084, Free PMC Article
    5. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin tyrosine ligase-like 4B
    Names
    CG3964-PA
    CG3964-PB
    CG3964-PC
    TTLL4B-PA
    TTLL4B-PB
    TTLL4B-PC
    NP_001260010.1
    NP_608810.1
    NP_722946.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3862668..3867507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164562.2 → NP_722946.1  tubulin tyrosine ligase-like 4B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQV6
      Related
      FBpp0077190
      Conserved Domains (1) summary
      pfam03133
      Location:504 → 799
      TTL; Tubulin-tyrosine ligase family

    2. NM_134966.3 → NP_608810.1  tubulin tyrosine ligase-like 4B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960F9
      Related
      FBpp0077191
      Conserved Domains (1) summary
      pfam03133
      Location:504 → 799
      TTL; Tubulin-tyrosine ligase family

    3. NM_001273081.2 → NP_001260010.1  tubulin tyrosine ligase-like 4B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQV6
      Conserved Domains (1) summary
      pfam03133
      Location:504 → 799
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T417 Q8T417
    Q960F9 Q960F9
    Q9VQV6 Q9VQV6

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