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    ncm nucampholin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncmprovided by FlyBase
    Official Full Name
    nucampholinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086707
    Locus tag
    Dmel_CG12750
    See related
    AllianceGenome:FB:FBgn0086707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12750; Dmel\CG12750; E-2a; l(2)SH0931; l(2)SH2 0931; Ncm; NCM
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Is expressed in several structures, including antennal anlage; central brain anlage; dorsal head epidermis anlage; embryonic/larval salivary gland; and posterior endoderm. Orthologous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ncm in Genome Data Viewer
    Location:
    36F5-36F5; 2-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18444507..18448957, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18444507..18448957, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44488 Neighboring gene Ribosomal protein S26 Neighboring gene bicoid stability factor Neighboring gene Nuclear transport factor-2-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster. Choudhury SR, et al. Elife, 2016 Nov 23. PMID 27879206, Free PMC Article
    2. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Barbosa I, et al. Nat Struct Mol Biol, 2012 Oct. PMID 22961380
    3. An Interaction Network of RNA-Binding Proteins Involved in Drosophila Oogenesis. Bansal P, et al. Mol Cell Proteomics, 2020 Sep. PMID 32554711, Free PMC Article
    4. Multi-level and lineage-specific interactomes of the Hox transcription factor Ubx contribute to its functional specificity. Carnesecchi J, et al. Nat Commun, 2020 Mar 13. PMID 32170121, Free PMC Article
    5. A genetic screen for dominant modifiers of a small-wing phenotype in Drosophila melanogaster identifies proteins involved in splicing and translation. Coelho CM, et al. Genetics, 2005 Oct. PMID 15998720, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucampholin
    Names
    CG12750-PA
    lethal (2) SH0931
    ncm-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18444507..18448957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136033.3 → NP_609877.2  nucampholin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609877.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WHI6, C9QPF2, Q8SXP2, Q95R63, Q9VJ87
      Related
      FBpp0080638
      Conserved Domains (3) summary
      PHA02896
      Location:1107 → 1300
      PHA02896; A-type inclusion like protein; Provisional
      smart00543
      Location:421 → 602
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02847
      Location:711 → 817
      MA3; MA3 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ87.3 Q9VJ87

    Gene LinkOut

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