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    Gtpx Glutathione peroxidase homolog with thioredoxin peroxidase activity [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38413, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Gtpxprovided by FlyBase
    Official Full Name
    Glutathione peroxidase homolog with thioredoxin peroxidase activityprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035438
    Locus tag
    Dmel_CG12013
    See related
    AllianceGenome:FB:FBgn0035438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0257455.17; CG12013; dGPX4; Dmel\CG12013; DmGpx; DmGPx; DmPHGPx; Gpx; GPx; GTPx; Gtpx-1; GTPx-1; PGTPx; phgpx; phGpx; PHGPx; Tpx1
    Summary
    Enables thioredoxin-dependent peroxiredoxin activity. Involved in intestinal stem cell homeostasis; response to endoplasmic reticulum stress; and response to oxidative stress. Located in Golgi apparatus. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and germline cell. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Gtpx in Genome Data Viewer
    Location:
    63D1-63D1; 3-8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3326265..3328626)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3326265..3328626)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class C Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 2 Neighboring gene Striatin interacting protein Neighboring gene long non-coding RNA:CR45380 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model. Dark C, et al. EMBO Rep, 2024 Apr. PMID 38429578, Free PMC Article
    2. The catalytic site of glutathione peroxidases. Tosatto SC, et al. Antioxid Redox Signal, 2008 Sep. PMID 18500926
    3. 5-Aminolevulinic acid bypasses mitochondrial complex I deficiency and corrects physiological dysfunctions in Drosophila. Nozawa N, et al. Hum Mol Genet, 2023 Aug 7. PMID 37364055, Free PMC Article
    4. Drosophila melanogaster "a potential model organism" for identification of pharmacological properties of plants/plant-derived components. Panchal K, et al. Biomed Pharmacother, 2017 May. PMID 28320100
    5. The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases. Maiorino M, et al. J Mol Biol, 2007 Jan 26. PMID 17098255

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. e catalytic mechanism of DmGPx, unlike that of selenocysteine (Sec)GPxs, involves formation of an internal disulfide that is pivotal to the interaction with Trx
      Title: The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-dependent peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    glutathione peroxidase homolog with thioredoxin peroxidase activity
    Names
    CG12013-PA
    CG12013-PC
    CG12013-PD
    Gtpx-PA
    Gtpx-PC
    Gtpx-PD
    PHGPx
    PHGPx with glutathione peroxidase activity
    glutathione peroxidase
    glutathione peroxidase I
    phospholipid hydroperoxide glutathione peroxidase
    NP_728868.1
    NP_728869.1
    NP_728870.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3326265..3328626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168024.2 → NP_728868.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRD4
      Related
      FBpp0072930
      Conserved Domains (1) summary
      cd00340
      Location:41 → 194
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    2. NM_168025.2 → NP_728869.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS7, Q8IRD3
      Related
      FBpp0072932
      Conserved Domains (1) summary
      cd00340
      Location:81 → 234
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    3. NM_168026.2 → NP_728870.1  glutathione peroxidase homolog with thioredoxin peroxidase activity, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728870.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZQ8
      Related
      FBpp0072931
      Conserved Domains (1) summary
      cd00340
      Location:12 → 165
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRD3 Q8IRD3
    Q8IRD4 Q8IRD4
    Q9VZQ8 Q9VZQ8

    Gene LinkOut

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