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    gny garnysstan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gnyprovided by FlyBase
    Official Full Name
    garnysstanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032234
    Locus tag
    Dmel_CG5091
    See related
    AllianceGenome:FB:FBgn0032234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alg6; CG5091; dAlg6; Dalg6; Dmel\CG5091; Gny[
    Summary
    Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Involved in chitin-based cuticle development. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gny in Genome Data Viewer
    Location:
    31D11-31D11; 2-41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10380103..10382864)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10380103..10382864)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene rhomboid-5 Neighboring gene uncharacterized protein Neighboring gene defective proboscis extension response 19 Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase 1 Neighboring gene mitochondrial ribosomal protein S7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. Shaik KS, et al. Glycobiology, 2011 Jun. PMID 21199819
    2. The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila. Zhang Y, et al. Dev Biol, 2014 Jun 15. PMID 24681004
    3. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    4. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article
    5. Molecular and comparative genetics of mental retardation. Inlow JK, et al. Genetics, 2004 Feb. PMID 15020472, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    garnysstan
    Names
    CG5091-PA
    CG5091-PB
    gny-PA
    gny-PB
    NP_001260338.1
    NP_609393.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10380103..10382864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135549.4 → NP_609393.1  garnysstan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609393.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960Z1, Q9VKX7
      UniProtKB/TrEMBL
      M9PB91
      Related
      FBpp0079595
      Conserved Domains (1) summary
      pfam03155
      Location:30 → 463
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    2. NM_001273409.1 → NP_001260338.1  garnysstan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960Z1, Q9VKX7
      UniProtKB/TrEMBL
      M9PB91
      Conserved Domains (1) summary
      pfam03155
      Location:30 → 463
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB91 M9PB91
    Q9VKX7.2 Q9VKX7

    Gene LinkOut

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