U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG18735 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59137, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG18735provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042098
    Locus tag
    Dmel_CG18735
    See related
    AllianceGenome:FB:FBgn0042098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG18735; SP22
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG18735 in Genome Data Viewer
    Location:
    58A1-58A1; 2-97 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21798017..21799195, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17685522..17686700, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lysyl oxidase-like 2 Neighboring gene uncharacterized protein Neighboring gene tracheal-prostasin Neighboring gene long non-coding RNA:CR9284

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Gene Expression Program for the Formation of Wing Cuticle in Drosophila. Sobala LF, et al. PLoS Genet, 2016 May. PMID 27232182, Free PMC Article
    2. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    3. Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. Díaz-Castillo C, et al. Mol Biol Evol, 2012 Sep. PMID 22427708
    4. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
    5. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG18735-PA
    NP_652645.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21798017..21799195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144388.2 → NP_652645.1  uncharacterized protein Dmel_CG18735 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7V4
      Related
      FBpp0071658
      Conserved Domains (2) summary
      smart00020
      Location:82 → 311
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:83 → 314
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7V4 Q9I7V4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools