sif still life [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sifprovided by FlyBase
Official Full Name: still lifeprovided by FlyBase
Primary source: FLYBASE:FBgn0085447
Locus tag: Dmel_CG34418
See related: AllianceGenome:FB:FBgn0085447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG32414; CG34418; CG5256; CG5406; Dmel\CG34418; Dm_3L:26493; lincRNA.447; RhoGEF; Sif; SIF; slf; Stilllife
Old locus tag: CG32414; CG5406; Dmel_CG32414; Dmel_CG5406
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including actin cytoskeleton organization; regulation of plasma membrane bounded cell projection organization; and visual perception. Located in synapse. Is expressed in several structures, including ganglia; organism subdivision; presumptive embryonic/larval central nervous system; spermatozoon; and synaptic neuropil domain. Used to study cataract 48 and neurodevelopmental disorder with language delay and seizures. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1) and TIAM2 (TIAM Rac1 associated GEF 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64E1-64E5; 3-15 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5657913..5749599)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5651013..5742699)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2149 (e-PCR)
- UniSTS:23630

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	TAS Traceable Author Statement more info	PubMed
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: still life

Names: CG34418-PA; CG34418-PB; CG34418-PC; CG34418-PF; CG34418-PI; CG34418-PJ; CG34418-PK; CG34418-PL; CG34418-PM; CG34418-PN; CG34418-PO; CG34418-PP; CG34418-PQ; CG34418-PR; sif-PA; sif-PB; sif-PC; sif-PF; sif-PI; sif-PJ; sif-PK; sif-PL; sif-PM; sif-PN; sif-PO; sif-PP; sif-PQ; sif-PR; still life type 1; still life type 2; still-life

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

5657913..5749599

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104048.2 → NP_001097518.2 still life, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097518.2

Status: REVIEWED

UniProtKB/TrEMBL

A8JNL4

Conserved Domains (7) summary

cd01818
Location:1122 → 1200

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00461
Location:35 → 144

WH1; WASP homology region 1

cd00160
Location:1446 → 1637

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1202 → 1289

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:841 → 966

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1640 → 1813

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:854 → 955

PH; PH domain
NM_001104049.4 → NP_001097519.2 still life, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097519.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91621, Q9VRN7

UniProtKB/TrEMBL

A8JNL6

Conserved Domains (7) summary

cd01818
Location:1122 → 1200

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00461
Location:35 → 144

WH1; WASP homology region 1

cd00160
Location:1437 → 1628

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1202 → 1289

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:841 → 966

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1631 → 1804

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:854 → 955

PH; PH domain
NM_001347763.1 → NP_001334674.1 still life, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

X2JC30
NM_001347764.1 → NP_001334675.1 still life, isoform Q [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WGZ0
NM_001274519.3 → NP_001261448.1 still life, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261448.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE98

Conserved Domains (7) summary

cd01818
Location:1132 → 1210

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00461
Location:35 → 140

WH1; WASP homology region 1

cd00160
Location:1456 → 1647

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1212 → 1299

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:851 → 976

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1650 → 1823

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:864 → 965

PH; PH domain
NM_001300018.2 → NP_001286947.1 still life, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286947.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCJ4

Conserved Domains (6) summary

cd01818
Location:932 → 1010

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

cd00160
Location:1256 → 1447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1012 → 1099

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:651 → 776

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1450 → 1623

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:664 → 765

PH; PH domain
NM_001274517.3 → NP_001261446.1 still life, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261446.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHI5

Conserved Domains (7) summary

cd01818
Location:1141 → 1219

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00461
Location:35 → 144

WH1; WASP homology region 1

cd00160
Location:1456 → 1647

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1221 → 1308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:860 → 985

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1650 → 1823

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:873 → 974

PH; PH domain
NM_001104047.5 → NP_001097517.1 still life, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097517.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQ62

Conserved Domains (7) summary

cd01818
Location:1122 → 1200

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00461
Location:35 → 144

WH1; WASP homology region 1

cd00160
Location:1437 → 1628

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1202 → 1289

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:841 → 966

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1631 → 1804

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:854 → 955

PH; PH domain
NM_168126.4 → NP_729084.1 still life, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729084.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91621, Q9VRN7

UniProtKB/TrEMBL

A8JNL6

Related

FBpp0111620

Conserved Domains (7) summary

cd01818
Location:1122 → 1200

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00461
Location:35 → 144

WH1; WASP homology region 1

cd00160
Location:1437 → 1628

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1202 → 1289

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:841 → 966

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1631 → 1804

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:854 → 955

PH; PH domain
NM_001414089.1 → NP_001401030.1 still life, isoform R [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

M9PBR2
NM_001274518.2 → NP_001261447.1 still life, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261447.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBR2

Conserved Domains (6) summary

cd00160
Location:642 → 833

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:398 → 485

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:37 → 162

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:836 → 1009

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:50 → 151

PH; PH domain

cl00155
Location:318 → 396

UBQ; Ubiquitin-like proteins
NM_206278.2 → NP_996000.1 still life, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996000.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91620, Q8MT93, Q9VRN8

Conserved Domains (6) summary

cd00160
Location:1426 → 1617

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1182 → 1269

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:821 → 946

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1620 → 1793

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:834 → 935

PH; PH domain

cl00155
Location:1102 → 1180

UBQ; Ubiquitin-like proteins
NM_079908.3 → NP_524647.2 still life, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524647.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91620

Related

FBpp0111621

Conserved Domains (6) summary

cd00160
Location:1417 → 1608

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1182 → 1269

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:821 → 946

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1611 → 1784

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:834 → 935

PH; PH domain

cl00155
Location:1102 → 1180

UBQ; Ubiquitin-like proteins
NM_001104046.4 → NP_001097516.3 still life, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097516.3

Status: REVIEWED

UniProtKB/TrEMBL

A8JNL5

Conserved Domains (6) summary

cd01818
Location:1102 → 1180

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

cd00160
Location:1426 → 1617

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00992
Location:1182 → 1269

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:821 → 946

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1620 → 1793

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:834 → 935

PH; PH domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0S0WGZ0		A0A0S0WGZ0
A8JNL4		A8JNL4
A8JNL5		A8JNL5
A8JNL6		A8JNL6
M9PBR2		M9PBR2
M9PE98		M9PE98
M9PHI5		M9PHI5
P91620.2		P91620
P91621.2		P91621
Q8IQ62		Q8IQ62
X2JC30		X2JC30
X2JCJ4		X2JCJ4