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    png pan gu [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31084, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pngprovided by FlyBase
    Official Full Name
    pan guprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000826
    Locus tag
    Dmel_CG11420
    See related
    AllianceGenome:FB:FBgn0000826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11420; Dmel\CG11420; EG:8D8.5; fs(1)M2; pan-gnu; Png; PNG
    Summary
    Enables protein serine/threonine kinase activity. Involved in egg activation and positive regulation of mitotic cell cycle, embryonic. Part of serine/threonine protein kinase complex. Is expressed in organism and unfertilized egg. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See png in Genome Data Viewer
    Location:
    1F4-1F4; 1-0.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1356488..1357601, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1250521..1251634, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sister-of-Sex-lethal Neighboring gene mir-4961 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition. Kronja I, et al. Cell Rep, 2014 Jun 12. PMID 24882012, Free PMC Article
    2. The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization. Shamanski FL, et al. Cell, 1991 Sep 20. PMID 1913810
    3. Premature translation of the Drosophila zygotic genome activator Zelda is not sufficient to precociously activate gene expression. Larson ED, et al. G3 (Bethesda), 2022 Aug 25. PMID 35876878, Free PMC Article
    4. Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases. Romanowski P, et al. Trends Cell Biol, 1996 May. PMID 15157470
    5. Regulation of the oocyte-to-zygote transition. Stitzel ML, et al. Science, 2007 Apr 20. PMID 17446393

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An unbiased biochemical screen for Pan Gu substrates identified the conserved translational repressor Trailer Hitch (TRAL).
      Title: Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition.
    2. Here the authors show that CDK1 phosphorylation of GNU negatively regulates PNG kinase activity.
      Title: Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation.
    3. These data argue that changes in poly(A) tail length are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepression of translation is an important alternative mechanism in Drosophila.
      Title: The Drosophila PNG kinase complex regulates the translation of cyclin B.
    4. In Drosophila, the PAN GU (PNG) triggers translation of SMAUG (SMG), a multifunctional posttranscriptional regulator conserved from yeast to humans.
      Title: SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.
    5. component of novel protein kinase complex that specifically regulates S-M cell cycles
      Title: The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in egg activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of serine/threonine protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pan gu
    Names
    CG11420-PA
    png-PA
    NP_477492.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1356488..1357601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058144.3 → NP_477492.1  pan gu [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46308, Q8SZA4
      Related
      FBpp0070225
      Conserved Domains (2) summary
      smart00220
      Location:11 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:9 → 214
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46308 O46308
    Q8SZA4 Q8SZA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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