Lztr1 Leucine zipper like transcription regulator 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lztr1provided by FlyBase
Official Full Name: Leucine zipper like transcription regulator 1provided by FlyBase
Primary source: FLYBASE:FBgn0040344
Locus tag: Dmel_CG3711
See related: AllianceGenome:FB:FBgn0040344
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3711; Dmel\CG3711; EG:BACR7A4.19; LZTR1; nowl
Summary: Involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of Ras protein signal transduction; and positive regulation of glycogen metabolic process. Predicted to be active in Golgi apparatus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); glioblastoma; hepatocellular carcinoma; neurilemmoma; and schwannomatosis (multiple). Orthologous to human LZTR1 (leucine zipper like post translational regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1D2-1D2; 1-0 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (922889..927582, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (816922..821615, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs.
Title: Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs.
LZTR1 regulates night-time sleep and metabolic homeostasis in Drosophila.
Title: Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1966 (e-PCR)
- UniSTS:30871

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IGI Inferred from Genetic Interaction more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine zipper like transcription regulator 1

Names: CG3711-PD; CG3711-PE; Lztr1-PD; Lztr1-PE; night owl

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

922889..927582 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130513.4 → NP_569869.2 leucine zipper like transcription regulator 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_569869.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V410

UniProtKB/TrEMBL

Q8SZY2

Related

FBpp0310018

Conserved Domains (7) summary

PLN02153
Location:392 → 536

PLN02153; epithiospecifier protein

PLN02193
Location:257 → 501

PLN02193; nitrile-specifier protein

sd00038
Location:302 → 355

Kelch; KELCH repeat [structural motif]

cd18308
Location:551 → 704

BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18309
Location:781 → 906

BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18505
Location:708 → 766

BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

cd18506
Location:902 → 962

BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
NM_001272185.2 → NP_001259114.1 leucine zipper like transcription regulator 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259114.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGD0

Conserved Domains (8) summary

PLN02153
Location:237 → 554

PLN02153; epithiospecifier protein

smart00225
Location:802 → 902

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14821
Location:707 → 766

SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

sd00038
Location:302 → 355

Kelch; KELCH repeat [structural motif]

pfam00651
Location:798 → 898

BTB; BTB/POZ domain

pfam01344
Location:466 → 509

Kelch_1; Kelch motif

pfam13415
Location:261 → 310

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:299 → 329

Kelch_5; Kelch motif