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    cerv cervantes [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cervprovided by FlyBase
    Official Full Name
    cervantesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030657
    Locus tag
    Dmel_CG15645
    See related
    AllianceGenome:FB:FBgn0030657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cerv; CG15645; Dmel\CG15645
    Summary
    Predicted to enable SUMO ligase activity. Predicted to be involved in double-strand break repair via homologous recombination and protein sumoylation. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in embryonic brain and organism. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cerv in Genome Data Viewer
    Location:
    13D4-13D4; 1-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15576986..15578171, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15471019..15472204, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nascent-associated complex beta-subunit-like, testis 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery. Ryu T, et al. Nucleus, 2016 Sep 2. PMID 27673416, Free PMC Article
    2. Fast protein evolution and germ line expression of a Drosophila parental gene and its young retroposed paralog. Betrán E, et al. Mol Biol Evol, 2006 Nov. PMID 16916943
    3. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. Li X, et al. PLoS One, 2013. PMID 23555814, Free PMC Article
    4. Condensins: universal organizers of chromosomes with diverse functions. Hirano T. Genes Dev, 2012 Aug 1. PMID 22855829, Free PMC Article
    5. Excess of amino acid substitutions relative to polymorphism between X-linked duplications in Drosophila melanogaster. Thornton K, et al. Mol Biol Evol, 2005 Feb. PMID 15483321

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cervantes
    Names
    CG15645-PA
    CG15645-PC
    CG15645-PD
    cerv-PA
    cerv-PC
    cerv-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15576986..15578171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298349.1 → NP_001285278.1  cervantes, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285278.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXT3
      Conserved Domains (1) summary
      cl17238
      Location:128 → 186
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_167453.3 → NP_727868.1  cervantes, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5IF49, Q8IR31
      Related
      FBpp0301753
      Conserved Domains (1) summary
      cl17238
      Location:75 → 133
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_132815.3 → NP_573043.1  cervantes, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXT3
      Related
      FBpp0088643
      Conserved Domains (1) summary
      cl17238
      Location:128 → 186
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR31 Q8IR31
    Q9VXT3 Q9VXT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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