U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ArgRS Arginyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32539, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ArgRSprovided by FlyBase
    Official Full Name
    Arginyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027093
    Locus tag
    Dmel_CG9020
    See related
    AllianceGenome:FB:FBgn0027093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-arg; CG9020; Dmel\CG9020; dRARS; RRS
    Summary
    Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; larval somatic muscle cell; and visceral muscle primordium. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ArgRS in Genome Data Viewer
    Location:
    13F10-13F10; 1-52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15841769..15844145, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15735802..15738178, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32582 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stunted

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Armstrong AR, et al. Development, 2014 Dec. PMID 25359724, Free PMC Article
    2. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
    3. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article
    4. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Liao TS, et al. Genetics, 2006 Sep. PMID 16849596, Free PMC Article
    5. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Arginyl-tRNA synthetase
    Names
    ArgRS-PA
    Arginyl-tRNA ligase
    CG9020-PA
    arginyl tRNA synthetase
    NP_573081.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15841769..15844145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132853.3 → NP_573081.1  Arginyl-tRNA synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VXN4
      Related
      FBpp0073965
      Conserved Domains (4) summary
      cd00671
      Location:197 → 463
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      smart00836
      Location:540 → 665
      DALR_1; DALR anticodon binding domain
      smart01016
      Location:81 → 171
      Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
      PLN02286
      Location:83 → 665
      PLN02286; arginine-tRNA ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXN4.1 Q9VXN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous