U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lft lowfat [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34405, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lftprovided by FlyBase
    Official Full Name
    lowfatprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032230
    Locus tag
    Dmel_CG13139
    See related
    AllianceGenome:FB:FBgn0032230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13139; Dmel\CG13139; Lft; LFT
    Summary
    Involved in imaginal disc-derived wing morphogenesis. Located in cytoplasm. Part of subapical complex. Is expressed in dorsal-ventral compartment boundary of the wing disc; embryonic/larval optic lobe; eye disc morphogenetic furrow; and imaginal disc. Orthologous to several human genes including LIX1L (limb and CNS expressed 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lft in Genome Data Viewer
    Location:
    31D10-31D10; 2-41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10364471..10366410)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10364471..10366410)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cullin-associated and neddylation-dissociated 1 Neighboring gene pimples Neighboring gene uncharacterized protein Neighboring gene rhomboid-5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins. Gridnev A, et al. Front Cell Dev Biol, 2022. PMID 35372364, Free PMC Article
    2. Drosophila lowfat, a novel modulator of Fat signaling. Mao Y, et al. Development, 2009 Oct. PMID 19710173, Free PMC Article
    3. Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway. Hogan J, et al. PLoS Genet, 2011 Feb. PMID 21379328, Free PMC Article
    4. Hippo signaling: growth control and beyond. Halder G, et al. Development, 2011 Jan. PMID 21138973, Free PMC Article
    5. Sleeping giants: emerging roles for the fat cadherins in health and disease. Sadeqzadeh E, et al. Med Res Rev, 2014 Jan. PMID 23720094

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of subapical complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lowfat
    Names
    CG13139-PA
    CG13139-PB
    Low fat
    lft-PA
    lft-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10364471..10366410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201846.2 → NP_001188775.1  lowfat, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VKY1
      Conserved Domains (1) summary
      pfam14954
      Location:24 → 255
      LIX1; Limb expression 1

    2. NM_135546.3 → NP_609390.1  lowfat, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609390.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VKY1
      Related
      FBpp0079592
      Conserved Domains (1) summary
      pfam14954
      Location:24 → 255
      LIX1; Limb expression 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKY1.1 Q9VKY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools