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    Cnot4 CCR4-NOT transcription complex subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnot4provided by FlyBase
    Official Full Name
    CCR4-NOT transcription complex subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0051716
    Locus tag
    Dmel_CG31716
    See related
    AllianceGenome:FB:FBgn0051716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CCR4-NOT; CG31716; CG5244; cg5251; CG5251; Cont4; Dmel\CG31716; dNOT4; not4; Not4; NOT4; Q8IPB9_DROME
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in cytoplasm. Predicted to be part of CCR4-NOT complex. Is expressed in organism; pole plasm; and primordial germ cell. Used to study heart disease. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cnot4 in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10396716..10403206)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10396716..10403206)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene daughterless Neighboring gene antisense RNA:CR45789 Neighboring gene Malate dehydrogenase 1 Neighboring gene uncharacterized protein Neighboring gene Like Sm protein 4 Neighboring gene Ionotropic receptor 31a Neighboring gene Ribosomal protein S27A Neighboring gene Intronic Protein 259

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Silencing of CCR4-NOT complex subunits affects heart structure and function. Elmén L, et al. Dis Model Mech, 2020 Jul 20. PMID 32471864, Free PMC Article
    2. Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis. Geng J, et al. Nat Commun, 2024 Feb 22. PMID 38388640, Free PMC Article
    3. What RNAi screens in model organisms revealed about microbicidal response in mammals? Abnave P, et al. Front Cell Infect Microbiol, 2014. PMID 25629007, Free PMC Article
    4. Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy. Wu Z, et al. Cell Metab, 2018 Jul 3. PMID 29861391, Free PMC Article
    5. Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex. Okada H, et al. PLoS One, 2015. PMID 25793896, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis.
      Title: Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis.
    2. Data show that Not4/CNOT4 is a novel positive regulator of the JAK/STAT pathway in Drosophila and in humans.
      Title: Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 4
    Names
    CG31716-PA
    CG31716-PB
    CG31716-PC
    CG31716-PD
    CG31716-PE
    CG31716-PG
    CG31716-PH
    CG31716-PI
    CG31716-PJ
    CG31716-PK
    CG31716-PL
    Cnot4-PA
    Cnot4-PB
    Cnot4-PC
    Cnot4-PD
    Cnot4-PE
    Cnot4-PG
    Cnot4-PH
    Cnot4-PI
    Cnot4-PJ
    Cnot4-PK
    Cnot4-PL
    cnot 4 homologue

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10396716..10403206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273414.1 → NP_001260343.1  CCR4-NOT transcription complex subunit 4, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260343.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB92
      Conserved Domains (2) summary
      cd12438
      Location:103 → 203
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    2. NM_001201847.2 → NP_001188776.1  CCR4-NOT transcription complex subunit 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRH8
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    3. NM_001273415.1 → NP_001260344.1  CCR4-NOT transcription complex subunit 4, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCL9
      Conserved Domains (2) summary
      cd12438
      Location:103 → 203
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    4. NM_164919.3 → NP_723578.1  CCR4-NOT transcription complex subunit 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKX1
      Related
      FBpp0079599
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    5. NM_001201848.2 → NP_001188777.1  CCR4-NOT transcription complex subunit 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB9
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    6. NM_164923.3 → NP_723582.1  CCR4-NOT transcription complex subunit 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723582.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKX1
      Related
      FBpp0079602
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    7. NM_164921.3 → NP_723580.1  CCR4-NOT transcription complex subunit 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKX1
      Related
      FBpp0079600
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    8. NM_164922.3 → NP_723581.1  CCR4-NOT transcription complex subunit 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKX1
      Related
      FBpp0079601
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    9. NM_001273413.1 → NP_001260342.1  CCR4-NOT transcription complex subunit 4, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFI0
      Conserved Domains (2) summary
      cd12438
      Location:103 → 203
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    10. NM_164920.3 → NP_723579.1  CCR4-NOT transcription complex subunit 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKX1
      Related
      FBpp0079603
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    11. NM_164924.2 → NP_723583.1  CCR4-NOT transcription complex subunit 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB9
      Related
      FBpp0079604
      Conserved Domains (2) summary
      cd12438
      Location:103 → 200
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRH8 M9MRH8
    M9PB92 M9PB92
    M9PCL9 M9PCL9
    M9PFI0 M9PFI0
    Q8IPB9 Q8IPB9
    Q9VKX1 Q9VKX1

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