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    Nup160 Nucleoporin 160kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup160provided by FlyBase
    Official Full Name
    Nucleoporin 160kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262647
    Locus tag
    Dmel_CG4738
    See related
    AllianceGenome:FB:FBgn0262647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4738; Dmel\CG4738; l(2)SH2 2055; l(2)SH2055; Nup; nup160; Nup160[mel]
    Summary
    Predicted to be a structural constituent of nuclear pore. Involved in double-strand break repair via homologous recombination; protein import into nucleus; and regulation of nucleocytoplasmic transport. Part of nuclear pore. Is expressed in adult head. Used to study nephrotic syndrome type 19. Human ortholog(s) of this gene implicated in nephrotic syndrome type 19. Orthologous to human NUP160 (nucleoporin 160). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nup160 in Genome Data Viewer
    Location:
    32D4-32D4; 2-44 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11123777..11129335)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11123777..11129335)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dynein axonemal assembly factor 4 Neighboring gene Csl4 Neighboring gene Replication factor C 38kD subunit Neighboring gene uncharacterized protein Neighboring gene homogentisate 1,2-dioxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A test of double interspecific introgression of nucleoporin genes in Drosophila. Sawamura K, et al. G3 (Bethesda), 2014 Aug 28. PMID 25172915, Free PMC Article
    2. Mutations in NUP160 Are Implicated in Steroid-Resistant Nephrotic Syndrome. Zhao F, et al. J Am Soc Nephrol, 2019 May. PMID 30910934, Free PMC Article
    3. Roles of mutation and selection in speciation: from Hugo de Vries to the modern genomic era. Nei M, et al. Genome Biol Evol, 2011. PMID 21903731, Free PMC Article
    4. Lineage-Specific Evolution of the Complex Nup160 Hybrid Incompatibility Between Drosophila melanogaster and Its Sister Species. Tang S, et al. Genetics, 2015 Aug. PMID 26022241, Free PMC Article
    5. Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes. Choi JY, et al. Genome Biol Evol, 2015 Oct 27. PMID 26507797, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Nup160sim gene is apparently involved in multiple reproductive isolation phenotypes in the cross between D. melanogaster and D. simulans.
      Title: Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila.
    2. Introduction of nuclear pore protein 160 (Nup160) from Drosophila simulans into Drosophila melanogaster caused female sterility in homozygous or hemizygous progeny.
      Title: Introgression of Drosophila simulans nuclear pore protein 160 in Drosophila melanogaster alone does not cause inviability but does cause female sterility.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin 160kD
    Names
    CG4738-PA
    CG4738-PB
    Nup160-PA
    Nup160-PB
    lethal (2) SH2055
    nuclear pore protein 160
    nucleoporin 160

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11123777..11129335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135649.2 → NP_609493.1  nucleoporin 160kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609493.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0KG65, C0KG66, C0KG67, C0KG68, C0KG69, C0KG70, C0KG71, C0KG74, C0KG75, Q6AWI7, Q9VKJ3
      UniProtKB/TrEMBL
      X2J9F3
      Related
      FBpp0079788
      Conserved Domains (1) summary
      pfam11715
      Location:28 → 530
      Nup160; Nucleoporin Nup120/160

    2. NM_001298903.1 → NP_001285832.1  nucleoporin 160kD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0KG65, C0KG66, C0KG67, C0KG68, C0KG69, C0KG70, C0KG71, C0KG74, C0KG75, Q6AWI7, Q9VKJ3
      UniProtKB/TrEMBL
      X2J9F3
      Conserved Domains (1) summary
      pfam11715
      Location:28 → 530
      Nup160; Nucleoporin Nup120/160
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKJ3.1 Q9VKJ3
    X2J9F3 X2J9F3

    Gene LinkOut

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