mtt mangetout [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mttprovided by FlyBase
Official Full Name: mangetoutprovided by FlyBase
Primary source: FLYBASE:FBgn0050361
Locus tag: Dmel_CG30361
See related: AllianceGenome:FB:FBgn0050361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.4; anon-WO0170980.5; CG18447; CG30361; CG8692; Dmel\CG30361; DmGluBR; DmGluRB; DmXR; Glu-RB; GluRB; Mtt; mXr
Summary: Enables G protein-coupled receptor activity. Involved in adult feeding behavior; phospholipase C-activating G protein-coupled receptor signaling pathway; and response to insecticide. Located in dendrite and plasma membrane. Is expressed in gustatory receptor neurons; labellum; labral sense organ neurons; and organism subdivision. Used to study congenital stationary night blindness 1B. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44D1-44D2; 2-59 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8473956..8532294, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4361461..4419799, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Drosophila Model Reveals the Potential Role for mtt in Retinal Disease.
Title: A Drosophila Model Reveals the Potential Role for mtt in Retinal Disease.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c8477350-8477110 mobile_element_type = transposon:INE-1{}3542
Loc: c8492278-8490623 mobile_element_type = transposon:Rt1b{}779
Loc: c8529627-8529573 mobile_element_type = transposon:INE-1{}3558

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
NOT enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables glutamate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT enables glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insecticide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mangetout

Names: CG30361-PC; CG30361-PD; CG30361-PE; CG30361-PF; CG30361-PG; DmX receptor; mXr; mtt-PC; mtt-PD; mtt-PE; mtt-PF; mtt-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8473956..8532294 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136542.3 → NP_610386.2 mangetout, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610386.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7F4, Q70GQ8

Conserved Domains (4) summary

cd06362
Location:73 → 527

PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)

pfam00003
Location:625 → 861

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:102 → 500

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:541 → 590

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_001144147.2 → NP_001137619.1 mangetout, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137619.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZT0

Conserved Domains (5) summary

cd06362
Location:393 → 847

PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)

pfam00003
Location:945 → 1181

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:422 → 820

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:861 → 910

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:73 → 152

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
NM_001273877.1 → NP_001260806.1 mangetout, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260806.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF15

Conserved Domains (5) summary

cd06362
Location:393 → 847

PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)

pfam00003
Location:945 → 1181

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:422 → 820

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:861 → 910

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:73 → 152

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
NM_165609.3 → NP_724683.2 mangetout, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724683.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7F5, Q70GQ8

Conserved Domains (4) summary

cd06362
Location:226 → 680

PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)

pfam00003
Location:778 → 1014

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:255 → 653

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:694 → 743

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_206058.2 → NP_995780.1 mangetout, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995780.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7F6

Conserved Domains (3) summary

pfam00003
Location:310 → 546

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam07562
Location:226 → 275

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:1 → 212

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily