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    Cyp4p3 Cytochrome P450 4p3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4p3provided by FlyBase
    Official Full Name
    Cytochrome P450 4p3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033397
    Locus tag
    Dmel_CG10843
    See related
    AllianceGenome:FB:FBgn0033397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4p3; CG10843; Dmel\CG10843
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval Malpighian tubule; embryonic/larval fat body; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4p3 in Genome Data Viewer
    Location:
    45B7-45B7; 2-60 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9242320..9244410)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5129825..5131915)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene hikaru genki Neighboring gene Cytochrome P450 4p2 Neighboring gene Cytochrome P450 4p1 Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene Protein kinase N Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytochrome P450s Cyp4p1 and Cyp4p2 associated with the DDT tolerance in the Drosophila melanogaster strain 91-R. Seong KM, et al. Pestic Biochem Physiol, 2019 Sep. PMID 31400775
    2. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article
    3. Comparative CYP-omic analysis between the DDT-susceptible and -resistant Drosophila melanogaster strains 91-C and 91-R. Seong KM, et al. Pest Manag Sci, 2018 Nov. PMID 29656515
    4. The molecular evolution of cytochrome P450 genes within and between drosophila species. Good RT, et al. Genome Biol Evol, 2014 Apr 20. PMID 24751979, Free PMC Article
    5. Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates. Ranade SS, et al. Dev Biol, 2008 Mar 15. PMID 18241855, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4p3
    Names
    CG10843-PA
    Cyp4p3-PA
    cytochrome P450
    NP_610473.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9242320..9244410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136629.3 → NP_610473.1  cytochrome P450 4p3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8Z5, Q9V559
      Related
      FBpp0087674
      Conserved Domains (1) summary
      pfam00067
      Location:54 → 505
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V559.3 Q9V559

    Gene LinkOut

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