Snx16 Sorting nexin 16 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Snx16provided by FlyBase
Official Full Name: Sorting nexin 16provided by FlyBase
Primary source: FLYBASE:FBgn0034265
Locus tag: Dmel_CG6410
See related: AllianceGenome:FB:FBgn0034265
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6410; Dmel\CG6410; DmSNX16; dSnx16; snx16; SNX16
Summary: Predicted to enable phosphatidylinositol binding activity. Involved in positive regulation of synaptic assembly at neuromuscular junction and receptor recycling. Located in early endosome; multivesicular body; and neuromuscular junction. Is active in presynaptic endosome. Is expressed in adult head and organism. Used to study polycythemia due to hypoxia. Orthologous to human SNX16 (sorting nexin 16). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17725030..17726847, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13612535..13614352, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISM Inferred from Sequence Model more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in receptor recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor recycling	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic endosome	IDA Inferred from Direct Assay more info	PubMed

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