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    Grx1t Glutaredoxin 1, testis-specific [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grx1tprovided by FlyBase
    Official Full Name
    Glutaredoxin 1, testis-specificprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034658
    Locus tag
    Dmel_CG7975
    See related
    AllianceGenome:FB:FBgn0034658
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7975; Dmel\CG7975; Grx-1; Grx1
    Summary
    Predicted to enable glutathione disulfide oxidoreductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be active in cytoplasm. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Grx1t in Genome Data Viewer
    Location:
    57F11-57F11; 2-96 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21757345..21757913)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17644850..17645418)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lamin B receptor Neighboring gene long non-coding RNA:CR44750 Neighboring gene long non-coding RNA:CR43983 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a role for the putative Drosophila hGRX1 orthologue in copper homeostasis. Mercer SW, et al. Biometals, 2016 Aug. PMID 27379771
    2. New insights on thioredoxins (Trxs) and glutaredoxins (Grxs) by in silico amino acid sequence, phylogenetic and comparative structural analyses in organisms of three domains of life. Mondal S, et al. Heliyon, 2022 Oct. PMID 36203893, Free PMC Article
    3. Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Svensson MJ, et al. Hereditas, 2007 Mar. PMID 17567437
    4. Quality of regulatory elements in Drosophila retrogenes. Bai Y, et al. Genomics, 2009 Jan. PMID 18848618, Free PMC Article
    5. Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. Piacentini L, et al. PLoS Genet, 2009 Oct. PMID 19798443, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutathione oxidoreductase (glutathione) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutaredoxin 1, testis-specific
    Names
    CG7975-PA
    Grx-1
    Grx1t-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21757345..21757913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137765.3 → NP_611609.1  glutaredoxin 1, testis-specific [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2D1
      Related
      FBpp0071631
      Conserved Domains (1) summary
      cd03419
      Location:33 → 113
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2D1 Q9W2D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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