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    CG4021 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4021provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034659
    Locus tag
    Dmel_CG4021
    See related
    AllianceGenome:FB:FBgn0034659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4021; Dmel\CG4021
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in adult head. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4021 in Genome Data Viewer
    Location:
    58A1-58A1; 2-97 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21773295..21774876)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17660800..17662381)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43984 Neighboring gene uncharacterized protein Neighboring gene Lysyl oxidase-like 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes. Ding Y, et al. PLoS Genet, 2010 Dec 23. PMID 21203494, Free PMC Article
    2. Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila. Yang S, et al. PLoS Genet, 2008 Jan. PMID 18208328, Free PMC Article
    3. Analysis of hunger-driven gene expression in the Drosophila melanogaster larval central nervous system. Ryuda M, et al. Zoolog Sci, 2008 Jul. PMID 18828662
    4. The drosophila melanogaster genome: translation factors and RNA binding proteins. Lasko P. J Cell Biol, 2000 Jul 24. PMID 10908586, Free PMC Article
    5. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4021-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21773295..21774876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137766.3 → NP_611610.2  uncharacterized protein Dmel_CG4021 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611610.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E6G6, Q9W2D0
      Related
      FBpp0071633
      Conserved Domains (1) summary
      cd02395
      Location:86 → 202
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2D0 Q9W2D0

    Gene LinkOut

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