CG42260 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG42260provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0259145
Locus tag: Dmel_CG42260
See related: AllianceGenome:FB:FBgn0259145
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13530; CG3536; dmCNG4; Dmel\CG42260; lincRNA.378
Old locus tag: Dmel_CG13530; Dmel_CG3536
Summary: Enables olfactory receptor activity. Involved in detection of chemical stimulus involved in sensory perception of smell and response to odorant. Predicted to be located in membrane. Predicted to be part of intracellular cyclic nucleotide activated cation channel complex. Predicted to be active in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59A3-59B1; 2-101 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22740999..22798289, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18628504..18685794, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of CG42260 in the NPF neurons reduced production of neuropeptide F (NPF) in Ll-1 cells, which in turn, led to reduction of neuronal responses of the ab3A neurons. Findings show the novel biological function of CG42260 in modulating olfactory responses to food odor through NPF
Title: A cyclic nucleotide-gated channel in the brain regulates olfactory modulation through neuropeptide F in fruit fly Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Bir17 (e-PCR), detects polymorphism
- UniSTS:141482

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables olfactory receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to odorant	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG42260-PA; CG42260-PB; CG42260-PD; CG42260-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22740999..22798289 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137873.3 → NP_611717.2 uncharacterized protein Dmel_CG42260, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611717.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9W1Z8

Conserved Domains (4) summary

COG0664
Location:609 → 737

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:615 → 729

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:323 → 545

Ion_trans; Ion transport protein

pfam07885
Location:472 → 537

Ion_trans_2; Ion channel
NM_001274212.1 → NP_001261141.1 uncharacterized protein Dmel_CG42260, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261141.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGC3

Conserved Domains (4) summary

COG0664
Location:884 → 1016

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:890 → 1008

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:598 → 820

Ion_trans; Ion transport protein

pfam07885
Location:747 → 812

Ion_trans_2; Ion channel
NM_001370013.1 → NP_001356969.1 uncharacterized protein Dmel_CG42260, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4P7VAE4

Conserved Domains (3) summary

cd00038
Location:890 → 1004

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam15548
Location:1084 → 1154

DUF4655; Domain of unknown function (DUF4655)

pfam00520
Location:581 → 819

Ion_trans; Ion transport protein
NM_137871.4 → NP_611715.3 uncharacterized protein Dmel_CG42260, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611715.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9W201

Conserved Domains (4) summary

COG0664
Location:884 → 1012

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:890 → 1004

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:598 → 820

Ion_trans; Ion transport protein

pfam07885
Location:747 → 812

Ion_trans_2; Ion channel