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    MnM myomesin and myosin binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MnMprovided by FlyBase
    Official Full Name
    myomesin and myosin binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035410
    Locus tag
    Dmel_CG14964
    See related
    AllianceGenome:FB:FBgn0035410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14964; CT34810; Dmel\CG14964; dMnM
    Summary
    Involved in sarcomere organization. Predicted to be active in M band. Is expressed in adult head; adult heart; and adult somatic muscle cell. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); lethal congenital contracture syndrome 4; and muscle tissue disease (multiple). Orthologous to human MYBPC1 (myosin binding protein C1); MYBPC2 (myosin binding protein C2); and MYBPC3 (myosin binding protein C3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MnM in Genome Data Viewer
    Location:
    63B9-63B9; 3-6 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3172817..3178580, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3172817..3178580, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene girdin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart. Auxerre-Plantié E, et al. Dis Model Mech, 2020 Dec 18. PMID 33033063, Free PMC Article
    2. Regular Exercise Rescues Heart Function Defects and Shortens the Lifespan of Drosophila Caused by dMnM Downregulation. Gu W, et al. Int J Environ Res Public Health, 2022 Dec 9. PMID 36554435, Free PMC Article
    3. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Lee JD, et al. Curr Biol, 2001 Jul 24. PMID 11509241
    4. Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation. Trevino CE, et al. Fertil Steril, 2021 Sep. PMID 34016428, Free PMC Article
    5. Third Chromosome Balancer Inversions Disrupt Protein-Coding Genes and Influence Distal Recombination Events in Drosophila melanogaster. Miller DE, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172211, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myomesin and myosin binding protein
    Names
    CG14964-PB
    MnM-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3172817..3178580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139522.3 → NP_647779.2  myomesin and myosin binding protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647779.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZT8
      Conserved Domains (5) summary
      cd00096
      Location:155 → 224
      Ig; Immunoglobulin domain
      smart00410
      Location:243 → 323
      IG_like; Immunoglobulin like
      cd00063
      Location:327 → 411
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:138 → 227
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:250 → 323
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZT8 Q9VZT8

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