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    CG14142 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14142provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036143
    Locus tag
    Dmel_CG14142
    See related
    AllianceGenome:FB:FBgn0036143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14142
    Summary
    Predicted to enable K48-linked deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination. Orthologous to several human genes including MINDY4B (MINDY family member 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14142 in Genome Data Viewer
    Location:
    68A9-68B1; 3-35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11173514..11176892)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11166614..11169992)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ALG10 alpha-1,2-glucosyltransferase Neighboring gene wntless Neighboring gene aarF domain containing kinase 5 Neighboring gene Glucuronyltransferase P Neighboring gene procollagen lysyl hydroxylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glucuronyltransferase GlcAT-P is required for stretch growth of peripheral nerves in Drosophila. Pandey R, et al. PLoS One, 2011. PMID 22132223, Free PMC Article
    2. Molecular Profiling of the Drosophila Antenna Reveals Conserved Genes Underlying Olfaction in Insects. Mohapatra P, et al. G3 (Bethesda), 2019 Nov 5. PMID 31527046, Free PMC Article
    3. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Zhou S, et al. Environ Health Perspect, 2016 Jul. PMID 26859824, Free PMC Article
    4. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K48-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14142-PB
    CG14142-PC
    CG14142-PD
    NP_001163415.1
    NP_001163416.1
    NP_648447.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11173514..11176892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169944.1 → NP_001163415.1  uncharacterized protein Dmel_CG14142, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JID2
      Conserved Domains (1) summary
      pfam13898
      Location:22 → 181
      DUF4205; Domain of unknown function (DUF4205)

    2. NM_001169945.1 → NP_001163416.1  uncharacterized protein Dmel_CG14142, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JID3
      Conserved Domains (1) summary
      pfam13898
      Location:22 → 191
      DUF4205; Domain of unknown function (DUF4205)

    3. NM_140190.2 → NP_648447.2  uncharacterized protein Dmel_CG14142, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648447.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTG6
      Conserved Domains (1) summary
      pfam13898
      Location:22 → 433
      DUF4205; Domain of unknown function (DUF4205)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JID2 E1JID2
    E1JID3 E1JID3
    Q9VTG6 Q9VTG6

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