U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG43373 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39835, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG43373provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263131
    Locus tag
    Dmel_CG43373
    See related
    AllianceGenome:FB:FBgn0263131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC; CG12436; CG32158; CG42513; dADCY5; Dmel\CG43373
    Old locus tag
    Dmel_CG12436; Dmel_CG32158; Dmel_CG42513
    Summary
    Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and cAMP biosynthetic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to several human genes including ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG43373 in Genome Data Viewer
    Location:
    73A3-73A5; 3-44 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16491838..16543370, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16484938..16536470, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene doublesex cognate 73A Neighboring gene argos Neighboring gene uncharacterized protein Neighboring gene scarlet Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Yoon W, et al. Commun Biol, 2022 Aug 25. PMID 36008531, Free PMC Article
    2. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746, Free PMC Article
    3. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378
    4. Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glands. Moulos P, et al. BMC Genomics, 2018 Jul 13. PMID 30005604, Free PMC Article
    5. Molecular Basis for Cephalic Mechanosensitivity of Drosophila Larvae. Zhang Z, et al. Neurosci Bull, 2020 Sep. PMID 32761438, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: c16494489-16494049 mobile_element_type = transposon:jockey{}1013

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG43373-PB
    CG43373-PC
    NP_001097622.2
    NP_730173.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16491838..16543370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168670.4 → NP_730173.3  uncharacterized protein Dmel_CG43373, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730173.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV68
      Conserved Domains (4) summary
      smart00044
      Location:686 → 881
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:722 → 895
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:949 → 1005
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:523 → 720
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. NM_001104152.4 → NP_001097622.2  uncharacterized protein Dmel_CG43373, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097622.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNU1
      Conserved Domains (4) summary
      smart00044
      Location:686 → 881
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:722 → 895
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:949 → 1005
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:523 → 720
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNU1 A8JNU1
    Q9VV68 Q9VV68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous