U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG10445 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40938, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG10445provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037531
    Locus tag
    Dmel_CG10445
    See related
    AllianceGenome:FB:FBgn0037531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10445
    Summary
    Predicted to enable ATP hydrolysis activity and ATP-dependent activity, acting on DNA. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in pole plasm and primordial germ cell. Orthologous to human TTF2 (transcription termination factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG10445 in Genome Data Viewer
    Location:
    84E5-84E5; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7916599..7920299, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3742321..3746021, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Riboflavin kinase Neighboring gene small Cajal body-specific RNA : MeU2-C41 Neighboring gene kipferl Neighboring gene lodestar Neighboring gene doublesex

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The XNP remodeler targets dynamic chromatin in Drosophila. Schneiderman JI, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706533, Free PMC Article
    2. Maternal RNAs encoding transcription factors for germline-specific gene expression in Drosophila embryos. Yatsu J, et al. Int J Dev Biol, 2008. PMID 18956321
    3. Identification of alternative splicing regulators by RNA interference in Drosophila. Park JW, et al. Proc Natl Acad Sci U S A, 2004 Nov 9. PMID 15492211, Free PMC Article
    4. Sex-specific expression of alternative transcripts in Drosophila. McIntyre LM, et al. Genome Biol, 2006. PMID 16934145, Free PMC Article
    5. Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division. Manzanero-Ortiz S, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768763, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG10445-PC
    CG10445-PD
    CG10445-PE

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7916599..7920299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260045.1 → NP_001246974.1  uncharacterized protein Dmel_CG10445, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHY2
      Conserved Domains (2) summary
      COG0553
      Location:90 → 945
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cl28899
      Location:209 → 534
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. NM_001300290.1 → NP_001287219.1  uncharacterized protein Dmel_CG10445, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287219.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGT5
      Conserved Domains (3) summary
      cd00046
      Location:371 → 482
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:760 → 891
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:211 → 654
      SNF2_N; SNF2 family N-terminal domain

    3. NM_141494.3 → NP_649751.2  uncharacterized protein Dmel_CG10445, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649751.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHY2
      Conserved Domains (2) summary
      COG0553
      Location:90 → 945
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cl28899
      Location:209 → 534
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGT5 A0A0B4LGT5
    Q9VHY2 Q9VHY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools