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    PK2-R1 Pyrokinin 2 receptor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41639, updated on 17-Dec-2024

    Summary

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    Official Symbol
    PK2-R1provided by FlyBase
    Official Full Name
    Pyrokinin 2 receptor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038140
    Locus tag
    Dmel_CG8784
    See related
    AllianceGenome:FB:FBgn0038140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.190; anon-WO0170980.191; CG8784; Dm CG8784; Dmel\CG8784; Pyrokinin2 R
    Summary
    Enables pyrokinin receptor activity. Involved in neuropeptide signaling pathway. Located in plasma membrane. Orthologous to human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PK2-R1 in Genome Data Viewer
    Location:
    87E6-87E6; 3-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13338330..13345106)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9164052..9170828)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pyrokinin 2 receptor 2 Neighboring gene methuselah-like 12 Neighboring gene Elongator complex protein 6 Neighboring gene Dicarboxylate carrier 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fraenkel's pupariation factor identified at last. Verleyen P, et al. Dev Biol, 2004 Sep 1. PMID 15302596
    2. Comparative neuroanatomy and genomics of hugin and pheromone biosynthesis activating neuropeptide (PBAN). Bader R, et al. Fly (Austin), 2007 Jul-Aug. PMID 18820431
    3. The pyrokinin/ pheromone biosynthesis-activating neuropeptide (PBAN) family of peptides and their receptors in Insecta: evolutionary trace indicates potential receptor ligand-binding domains. Jurenka R, et al. Insect Mol Biol, 2011 Jun. PMID 21199021
    4. Synaptic transmission parallels neuromodulation in a central food-intake circuit. Schlegel P, et al. Elife, 2016 Nov 15. PMID 27845623, Free PMC Article
    5. An obligatory role for neurotensin in high-fat-diet-induced obesity. Li J, et al. Nature, 2016 May 19. PMID 27193687, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables pyrokinin receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyrokinin 2 receptor 1
    Names
    CG8784-PA
    PK2-R1-PA
    hugin receptor
    pyrokinin 2 receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13338330..13345106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169507.3 → NP_731790.1  pyrokinin 2 receptor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8ITD1, Q9VFW5
      Related
      FBpp0082213
      Conserved Domains (2) summary
      pfam00001
      Location:124 → 388
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:114 → 242
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WNX8 Q6WNX8
    Q8ITD1 Q8ITD1
    Q9VFW5 Q9VFW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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