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    Fer2 48 related 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fer2provided by FlyBase
    Official Full Name
    48 related 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038402
    Locus tag
    Dmel_CG5952
    See related
    AllianceGenome:FB:FBgn0038402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHa33; CG5952; Dmel\CG5952; fer2
    Summary
    Enables chromatin binding activity. Involved in positive regulation of autophagy and response to oxidative stress. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Used to study Parkinson's disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fer2 in Genome Data Viewer
    Location:
    89B6-89B6; 3-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16149369..16151312, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11975091..11977034, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Akt kinase Neighboring gene Stubble Neighboring gene MICOS subunit 26/27 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43472 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-cell RNA sequencing in Drosophila: Technologies and applications. Li H. Wiley Interdiscip Rev Dev Biol, 2021 Sep. PMID 32940008, Free PMC Article
    2. Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit. Rudisill SS, et al. Biol Trace Elem Res, 2019 May. PMID 30022428, Free PMC Article
    3. A conserved role for p48 homologs in protecting dopaminergic neurons from oxidative stress. Bou Dib P, et al. PLoS Genet, 2014 Oct. PMID 25340742, Free PMC Article
    4. Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons. Tas D, et al. PLoS Genet, 2018 Mar. PMID 29529025, Free PMC Article
    5. Dopaminergic systems create reward seeking despite adverse consequences. Jovanoski KD, et al. Nature, 2023 Nov. PMID 37880370, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dFOXO and FER2 act in parallel to protect protocerebral anterior medial neurons from different forms of cellular stress.
      Title: Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons.
    2. hlh-13, the worm homolog of p48, is also expressed in DA neurons. Unlike the fly counterpart, hlh-13 loss-of-function does not impair development or survival of DA neurons under normal growth conditions
      Title: A conserved role for p48 homologs in protecting dopaminergic neurons from oxidative stress.
    3. The transcription factor Fer2 is expressed in ventral lateral neurons; it is required for the specification of lateral neurons and therefore their ability to drive locomotor rhythms.
      Title: Dissecting differential gene expression within the circadian neuronal circuit of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    48 related 2
    Names
    48-related 2
    48-related-2
    CG5952-PB
    CG5952-PC
    CG5952-PD
    CG5952-PE
    Fer2-PB
    Fer2-PC
    Fer2-PD
    Fer2-PE
    ferritin 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16149369..16151312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300431.1 → NP_001287360.1  48 related 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH77, Q0IGS8
      Conserved Domains (1) summary
      pfam00010
      Location:148 → 201
      HLH; Helix-loop-helix DNA-binding domain

    2. NM_079652.3 → NP_524376.2  48 related 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524376.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGS8, Q9VEY3
      Conserved Domains (1) summary
      cl00081
      Location:144 → 207
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    3. NM_001300429.1 → NP_001287358.1  48 related 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIA7, Q0IGS8
      Conserved Domains (1) summary
      pfam00010
      Location:148 → 206
      HLH; Helix-loop-helix DNA-binding domain

    4. NM_001300430.1 → NP_001287359.1  48 related 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH78, Q0IGS8
      Conserved Domains (1) summary
      pfam00010
      Location:148 → 210
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH77 A0A0B4LH77
    A0A0B4LH78 A0A0B4LH78
    A0A0B4LIA7 A0A0B4LIA7
    Q3YNF2 Q3YNF2
    Q9VEY3 Q9VEY3

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