U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GckIII Germinal centre kinase III [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42064, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GckIIIprovided by FlyBase
    Official Full Name
    Germinal centre kinase IIIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266465
    Locus tag
    Dmel_CG5169
    See related
    AllianceGenome:FB:FBgn0266465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5169; dGckIII; dGCKIII; Dmel\CG5169; Gck III; GCKIII; STLK3; wheezy
    Summary
    Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Involved in septate junction assembly and trachea morphogenesis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including STK24 (serine/threonine kinase 24) and STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GckIII in Genome Data Viewer
    Location:
    89E12-89E12; 3-59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17085513..17087988)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12911235..12913710)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Keap1 Neighboring gene kugelkern Neighboring gene chromosome alignment defect 1 Neighboring gene cheerio Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. Brandt A, et al. Aging Cell, 2008 Aug. PMID 18494863
    2. A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster. Poon CLC, et al. Dev Cell, 2018 Dec 3. PMID 30458981, Free PMC Article
    3. Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Perrimon N, et al. Genetics, 2007 Jan. PMID 17244760, Free PMC Article
    4. STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity. De Jamblinne CV, et al. J Cell Biol, 2020 Nov 2. PMID 32960945, Free PMC Article
    5. The mammalian family of sterile 20p-like protein kinases. Delpire E. Pflugers Arch, 2009 Sep. PMID 19399514

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCM3 and GCKIII prevent tube dilation in Drosophila trachea; tube dilation is suppressed by reduction of NSF2
      Title: Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trachea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    germinal centre kinase III
    Names
    CG5169-PA
    GckIII-PA
    germinal center kinase III
    wheezy
    NP_650596.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17085513..17087988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142339.3 → NP_650596.1  germinal centre kinase III [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGS1, Q9VEN3
      Related
      FBpp0082840
      Conserved Domains (2) summary
      smart00220
      Location:13 → 263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:12 → 283
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGS1 Q8IGS1
    Q9VEN3 Q9VEN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools