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    Ino80 INO80 complex subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ino80provided by FlyBase
    Official Full Name
    INO80 complex subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0289122
    Locus tag
    Dmel_CG31212
    See related
    AllianceGenome:FB:FBgn0289122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14279; CG18491; CG31212; CG3602; dIno80; dINO80; Dmel\CG31212; Gaiano strain; INO80; psg25; Tel
    Summary
    Enables transcription cis-regulatory region binding activity. Involved in negative regulation of DNA-templated transcription and regulation of development, heterochronic. Located in chromatin; nucleus; and polytene chromosome. Part of Ino80 complex. Is expressed in adult brain cell body rind and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ino80 in Genome Data Viewer
    Location:
    92A2-92A3; 3-66 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19368995..19403153, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15194717..15228875, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43258 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene aprataxin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility. Walter MF, et al. Chromosoma, 2007 Feb. PMID 17089138, Free PMC Article
    2. The regulatory function of dIno80 correlates with its DNA binding activity. Jain S, et al. Gene, 2020 Mar 30. PMID 31954859
    3. A Pooled Sequencing Approach Identifies a Candidate Meiotic Driver in Drosophila. Wei KH, et al. Genetics, 2017 May. PMID 28258181, Free PMC Article
    4. Functional separation of genetic factors telomere elongation (Tel) and enhancer of terminal gene conversion (E(tc)) involved in telomere elongation in Drosophila melanogaster. Proskuryakov KA, et al. Dokl Biochem Biophys, 2008 Jul-Aug. PMID 18853771
    5. Altered Localization of Hybrid Incompatibility Proteins in Drosophila. Cooper JC, et al. Mol Biol Evol, 2019 Aug 1. PMID 31038678, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that, dIno80 has a sequence preference for interaction with DNA leading to transcriptional changes
      Title: The regulatory function of dIno80 correlates with its DNA binding activity.
    2. this study represents the first characterization of a bona fide ino80 mutation in any metazoan, raising the possibility that the functions of ino80 in transcriptional repression and developmental timing are evolutionarily conserved.
      Title: INO80-dependent regression of ecdysone-induced transcriptional responses regulates developmental timing in Drosophila.
    3. The localization of dINO80 to sequences upstream of misexpressed genes in vivo shows that dINO80 is involved in homeotic gene regulation and probably through its interactions with PcG-trxG complexes.
      Title: Chromatin remodeling protein INO80 has a role in regulation of homeotic gene expression in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ATP-dependent activity, acting on DNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    INO80 complex subunit
    Names
    CG31212-PA
    Ino80-PA
    telomere elongation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19368995..19403153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169854.2 → NP_732413.1  INO80 complex subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9F9, Q9VDY1
      UniProtKB/TrEMBL
      H9ZYP6
      Related
      FBpp0083185
      Conserved Domains (4) summary
      cd00046
      Location:555 → 700
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:538 → 840
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1156 → 1269
      Helicase_C; Helicase conserved C-terminal domain
      pfam13892
      Location:313 → 438
      DBINO; DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDY1.2 Q9VDY1

    Gene LinkOut

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