U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Spase22-23 Spase 22/23-subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42885, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Spase22-23provided by FlyBase
    Official Full Name
    Spase 22/23-subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039172
    Locus tag
    Dmel_CG5677
    See related
    AllianceGenome:FB:FBgn0039172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5677; Dmel\CG5677; Spase22/23
    Summary
    Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including adult head; adult heart; border follicle cell; egg chamber; and gland. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Spase22-23 in Genome Data Viewer
    Location:
    95F3-95F3; 3-84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24228342..24230035, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20054064..20055757, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene twin Neighboring gene uncharacterized protein Neighboring gene caravaggio Neighboring gene long non-coding RNA:CR45217 Neighboring gene Sp1-like factor for pairing sensitive-silencing Neighboring gene long non-coding RNA:CR44092 Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 95EF Neighboring gene small Cajal body-specific RNA : MeU2-G25 Neighboring gene multiple ankyrin repeats single KH domain

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum. Guan J, et al. Arch Insect Biochem Physiol, 2018 Mar. PMID 29265467
    2. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
    3. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article
    4. Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. Liu J, et al. Dev Biol, 2008 Jan 15. PMID 18067885, Free PMC Article
    5. A hormonal cue promotes timely follicle cell migration by modulating transcription profiles. Manning L, et al. Mech Dev, 2017 Dec. PMID 28610887, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    spase 22/23-subunit
    Names
    CG5677-PA
    CG5677-PB
    Spase22-23-PA
    Spase22-23-PB
    Spase22/23-subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24228342..24230035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260350.2 → NP_001247279.1  spase 22/23-subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCA9
      UniProtKB/TrEMBL
      A0A0B4K7R1
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 172
      SPC22; Signal peptidase subunit

    2. NM_142977.5 → NP_651234.1  spase 22/23-subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651234.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCA9
      UniProtKB/TrEMBL
      A0A0B4K7R1
      Related
      FBpp0083949
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 172
      SPC22; Signal peptidase subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7R1 A0A0B4K7R1
    Q9VCA9.1 Q9VCA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools