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    mIF2 mitochondrial translation initiation factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mIF2provided by FlyBase
    Official Full Name
    mitochondrial translation initiation factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039588
    Locus tag
    Dmel_CG12413
    See related
    AllianceGenome:FB:FBgn0039588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12413; Dmel\CG12413
    Summary
    Predicted to enable GTPase activity; tRNA binding activity; and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mIF2 in Genome Data Viewer
    Location:
    98D4-98D4; 3-96 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28542274..28544817, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24367996..24370539, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Papilin Neighboring gene long non-coding RNA:CR43126 Neighboring gene fork head

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic signatures of experimental adaptive radiation in Drosophila. Michalak P, et al. Mol Ecol, 2019 Feb. PMID 30375065
    2. Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Zenk F, et al. Science, 2017 Jul 14. PMID 28706074
    3. Mitochondrial DNA quality control in the female germline requires a unique programmed mitophagy. Palozzi JM, et al. Cell Metab, 2022 Nov 1. PMID 36323236
    4. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article
    5. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial translation initiation factor 2
    Names
    CG12413-PA
    mIF2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28542274..28544817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143364.3 → NP_651621.2  mitochondrial translation initiation factor 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651621.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS23, Q9VAV2
      Related
      FBpp0084662
      Conserved Domains (5) summary
      cd01887
      Location:163 → 327
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      COG0532
      Location:158 → 689
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam11987
      Location:482 → 575
      IF-2; Translation-initiation factor 2
      cd03692
      Location:593 → 680
      mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
      cd03702
      Location:336 → 431
      IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS23 Q8MS23
    Q9VAV2 Q9VAV2

    Gene LinkOut

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