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    Nepl18 Neprilysin-like 18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43410, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl18provided by FlyBase
    Official Full Name
    Neprilysin-like 18provided by FlyBase
    Primary source
    FLYBASE:FBgn0039611
    Locus tag
    Dmel_CG14528
    See related
    AllianceGenome:FB:FBgn0039611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14528; Dmel\CG14528
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl18 in Genome Data Viewer
    Location:
    98F1-98F1; 3-97 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28875621..28877805)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24701343..24703527)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene sponge Neighboring gene Innexin 3 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 17 Neighboring gene Neprilysin-like 19 Neighboring gene Neprilysin-like 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic basis of variation in sexual aggression: Evolution versus social plasticity. Scott AM, et al. Mol Ecol, 2022 May. PMID 35313034
    2. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    4. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Mastushita-Sakai T, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547833, Free PMC Article
    5. Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. Yasuhara JC, et al. PLoS Genet, 2008 Jan. PMID 18208336, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 18
    Names
    CG14528-PA
    Nepl18-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28875621..28877805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143386.3 → NP_651643.1  Neprilysin-like 18 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRG3, Q9VAS2
      Related
      FBpp0084698
      Conserved Domains (2) summary
      cd08662
      Location:58 → 679
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:54 → 682
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRG3 Q8MRG3
    Q9VAS2 Q9VAS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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